Tag: UPR
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Calcium Signaling and ER Protein Quality: A Crucial Cellular Choreography
Introduction: The Calcium-ER Quality Link Calcium ions (Ca2+) are master regulators of numerous cellular processes, from muscle contraction to neurotransmitter release. Beyond these well-known roles, Ca2+ signaling plays a pivotal part in maintaining protein quality within the endoplasmic reticulum (ER). The ER is the cellular site where secretory and membrane proteins are folded, modified, and…
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Calcium Signaling: The Key to Protein Quality in the Endoplasmic Reticulum
Understanding the ER and its Protein Quality Challenge The endoplasmic reticulum (ER) is a central hub for protein synthesis, folding, and trafficking within the cell. A critical aspect of cellular health is ensuring that proteins entering the secretory pathway are correctly folded and functional. Calcium (Ca2+) signaling plays a pivotal yet intricate role in orchestrating…
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ER Stress Biomarkers in COPD: Key Indicators for Management
Introduction Chronic obstructive pulmonary disease (COPD) encompasses a spectrum of chronic inflammatory lung diseases characterized by persistent airflow limitation and progressive decline in lung function. Beyond traditional risk factors like tobacco exposure, accumulating evidence highlights the role of cellular stress responses—particularly endoplasmic reticulum (ER) stress—in COPD pathogenesis. ER stress activates the unfolded protein response (UPR),…
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Ganoderma lucidum and Liver Health: Protecting the Liver from High-Fat Diet Lipotoxicity
Understanding the Challenge: High-Fat Diets and Liver Health Long-term consumption of high-fat diets (HFD) is known to impose lipotoxic stress on multiple organs, with the liver bearing a heavy burden. As fat accumulates, hepatocytes face metabolic dysfunction, inflammation, and cell injury that can progress to steatosis and liver disease. This emerging research explores not only…
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Ganoderma lucidum Shields Liver Damage from High-Fat Diets
Overview: High-Fat Diets, Liver Lipotoxicity, and the Search for Protection Long-term consumption of a high-fat diet (HFD) is linked to progressive liver damage, metabolic dysfunction, and fears of nonalcoholic fatty liver disease. In a recent study, researchers investigated how HFD drives lipid accumulation, inflammatory responses, and cellular stress in the liver, and whether Ganoderma lucidum…
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Ganoderma lucidum protects the liver from high-fat diet lipotoxicity: new insights
Background: The challenge of high-fat diet lipotoxicity A sustained high-fat diet (HFD) can drive metabolic derangements that disproportionately affect the liver. Lipotoxicity from excess fatty acids and lipid intermediates promotes hepatic steatosis, liver injury, and inflammation, contributing to metabolic diseases such as non-alcoholic fatty liver disease (NAFLD). Understanding the dynamic effects of HFD on liver…