Tag: tumor microenvironment
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Engineered CAR T cells show promise against solid tumors
A breakthrough design for solid tumors: CAR T cells deliver IL-12 and PD-L1 blocker Chimeric antigen receptor (CAR) T cell therapy has transformed treatments for certain blood cancers, but solid tumors such as ovarian, prostate, breast, and pancreatic cancers have posed stubborn challenges. A collaborative effort from USC Norris Comprehensive Cancer Center and City of…
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Engineered CAR T Cells Target Solid Tumors with IL-12 PD-L1 Fusion
A new approach targets solid tumors Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment landscape for certain blood cancers, but solid tumors—such as prostate, breast, lung, and ovarian cancers—have remained stubborn hurdles. A collaboration between USC Norris Comprehensive Cancer Center and City of Hope has yielded a promising solution: engineering CAR T…
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Radiomics in NPC: AI Predicts Immunotherapy Response More Accurately Than Clinical Models
Unlocking Radiomics for Nasopharyngeal Carcinoma (NPC) Nasopharyngeal carcinoma (NPC) is a highly aggressive cancer often diagnosed at locally advanced stages. In recent years, immune checkpoint inhibitors (such as PD-1 blockers) have offered new hope, yet most patients derive only limited durable benefit. A multicenter study led by researchers from the First Affiliated Hospital of Jinan…
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Radiomics Outperforms Clinical Models for NPC Immunotherapy Outcomes
Revolutionizing NPC management with radiomics Nasopharyngeal carcinoma (NPC) remains challenging, with many patients presenting at locally advanced stages. Immunotherapy, including PD-1 blockade, has improved outcomes but durable benefit is limited to a subset. The quest for robust, non-invasive biomarkers to predict response and guide treatment has become urgent. Key multicenter study shows radiomics outperforms clinical…
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Radiomics Surpasses Clinical Models in NPC Treatment Outcome Prediction
Groundbreaking Insight: Radiomics Elevates NPC Immunotherapy Prediction Nasopharyngeal carcinoma (NPC) remains a highly aggressive cancer, with most patients presenting at locally advanced stages. While immune checkpoint inhibitors, including PD-1 blockade, have reshaped treatment strategies, only a subset of patients derives durable benefit. A multicenter study led by Prof. Shuixing Zhang and Prof. Bin Zhang from…
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The Silent Revolution of Patient-Derived Organoids in Oncology
The Silent Revolution: Patient-D Derived Organoids in Oncology In modern oncology, a quiet revolution is unfolding. Patient-derived organoids, or PDOs, are three-dimensional cultures grown from a patient’s tumor tissue. They faithfully mirror the architecture, cellular diversity, and functional traits of the original tumor far better than traditional two-dimensional models. By recapitulating the tumor microenvironment, PDOs…
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Silent Revolution in Oncology: The Rise of Patient-Derived Organoids
Introduction A quiet revolution is reshaping cancer research: patient‑derived organoids (PDOs) are elevating the study of tumors from flat, simplified systems to dynamic, three‑dimensional models that mirror the biology of individual cancers. Organoids are tiny, self‑organizing mini-tumors grown from a patient’s tissue or stem cells. In oncology, they recapitulate the architecture, genetic diversity, and microenvironment…
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Silent Revolution of Patient-Derived Organoids in Oncology
Introduction: A Silent Revolution in Cancer Research The emergence of patient-derived organoids (PDOs) has quietly transformed oncology, enabling models that closely mirror human tumors. These three-dimensional structures, established from patient tissues—spanning gastrointestinal, pulmonary, breast, and other cancers—recreate key features of the tumor microenvironment (TME) and preserve intratumoral heterogeneity. As powerful platforms for drug screening, neoantigen…
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How Physical Stress Pushes Cancer Cells Into Dangerous New States
The Connection Between Physical Stress and Cancer Cells Cancer cells showcase a remarkable ability to adapt as they spread throughout the body, often becoming more invasive and aggressive. One significant factor contributing to this adaptability is physical stress, particularly pressure from surrounding tissues. This mechanical stress can activate various programs within cancer cells, leading to…