Tag: tumor microenvironment
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IFITM3-MET Interaction Drives Osimertinib Resistance in EGFR-Mutant NSCLC
Overview: A New Mechanism Behind Osimertinib Resistance in EGFR-Mutant NSCLC Osimertinib has transformed the treatment landscape for patients with EGFR-mutant non-small cell lung cancer (NSCLC). Yet resistance remains a major hurdle. A recent study identifies a non-genetic mechanism: the membrane protein IFITM3 interacts with MET to activate the PI3K-AKT signaling axis, enabling tumor cells to…
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Switching Immune-Cold Tumors to Immune-Hot: A Breakthrough Path to Durable Cancer Immunity
Turning the Tide on Immune-Cold Tumors In a pivotal study published in Nature Immunology, scientists reveal a strategy that could make aggressive, immune-suppressive tumors more vulnerable to the body’s defenses. Funded by the National Cancer Institute/NIH, the research builds on prior work in breast cancer to show that transforming the tumor microenvironment can awaken a…
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Switching Immune Cold Tumors to Immune Hot: A Breakthrough in Cancer immunotherapy
Overview: Turning immune-cold tumors into immune-hot targets In a significant advance for cancer immunotherapy, researchers have identified a strategy to reprogram immune-cold tumors—those that typically evade detection—into immune-hot tumors that recruit and coordinate immune cells to attack cancer. The study, recently published in Nature Immunology, builds on decades of work to harness the body’s own…
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Researchers Discover a Switch that Transforms Immune-Cold Tumors into Immune-Hot, Boosting Cancer Therapy
Transforming Immune-Cold Tumors into Immune-Active Targets Cancer research has long grappled with tumors that evade the body’s defenses. A recent study published in Nature Immunology, backed by the National Cancer Institute/NIH, reports a promising strategy to convert these immune-cold tumors into immune-hot ones. By priming the tumor environment with immune-activating signals, researchers observed a robust,…
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Nanomedicine Emerges as a Key Tool to Boost Cancer Immunotherapy
Nanomedicine and Immunotherapy: A New Synergy The landscape of cancer treatment is rapidly evolving as researchers explore how nanotechnology can complement and strengthen immunotherapy. Recent back-to-back reviews in Nature Cancer and Trends in Cancer highlight nanomedicine as a versatile approach to reprogram the immune system and overcome the immune evasion strategies employed by solid tumors.…
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Nanomedicine Boosts Cancer Immunotherapy: Reprogramming the Immune Fight
Nanomedicine Emerges as a Key Tool in Cancer Immunotherapy Researchers at the Fralin Biomedical Research Institute at Virginia Tech (VTC) and their collaborators are exploring how nanotechnology and immunology intersect to enhance cancer immunotherapy. Recent back-to-back review articles published in Nature Cancer and Trends in Cancer synthesize current insights on how nanoengineering can reprogram the…
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Engineered Salmonella therapy delivers immune payloads to combat cancer
Breakthrough in bacterial immunotherapy: ACTM-838 targets solid tumors Solid tumors have long posed a challenge for immunotherapy, often creating an immune-suppressive microenvironment that thwarts even the most advanced treatments. A new study published in Oncotarget (Volume 16, October 6, 2025) introduces ACTM-838, a novel systemically delivered bacterial immunotherapy designed to enrich in solid tumors and…
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Engineered Salmonella Therapy Delivers Immune Payloads to Fight Cancer
New Bacterial Immunotherapy Targets Solid Tumors Researchers have unveiled ACTM-838, a novel, systemically delivered bacterial immunotherapy designed to enrich solid tumors with immune-stimulating payloads. Published in Volume 16 of Oncotarget on October 6, 2025, the study demonstrates how a specially engineered Salmonella Typhimurium strain can safely localize to tumors and deliver potent immune activators directly…
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Disputation Spotlight: Unraveling Tumor-associated Adaptive NK Cells — Yizhe Sun
Overview On October 24, 2025, Yizhe Sun will defend a pivotal dissertation at Karolinska Institutet, delving into the phenotypic features and functional mechanisms of tumor-associated adaptive natural killer (NK) cells. Hosted in Lagerlöf, plan 4, inside the KI campus, the disputation brings together renowned researchers and clinicians to evaluate a significant advance in tumor immunology.…
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Cancer Cells’ Hidden Power Source Revealed
Introduction: A surprising energy boost under pressure Scientists have uncovered a surprising mechanism that helps cancer cells survive the brutal mechanical gauntlets they must run to spread through the body. When cancer cells squeeze through dense tumor matrices, pores in blood vessels, and the bloodstream itself, they encounter intense physical stress. A team at the…