Tag: tumor microenvironment
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Mark’s Deadly Cancer Will Return: Scientists Explain Why It Reappears
Introduction: A personal story reflects a national concern Mark Norris, a 52-year-old man whose life has already been touched by cancer, faces the fear that his deadly disease will return. The narrative of his illness is not merely medical; it is a window into a broader, pressing question in oncology: why do some cancers recur…
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Pancreatic Cancer Research Project Targets Seeds of Metastasis
New Frontiers in Pancreatic Cancer Research Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest forms of cancer, with a five-year survival rate that has stubbornly lingered in the single digits. A recent research initiative is focusing on a critical phase of disease progression: the early steps that allow pancreatic cancer cells to seed distant…
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Pancreatic Cancer Research Targets Seeds of Metastasis
New frontiers in the fight against pancreatic cancer Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal forms of cancer, often diagnosed at late stages when treatment options are limited. A leading reason for its grim prognosis is the way PDAC quickly seeds metastasis, spreading to the liver, lungs, and other organs. In a…
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Inflammation Drives Early Lung Cancer, MD Anderson Study Finds
Overview: Inflammation as an Early Driver of Lung Cancer A groundbreaking study by researchers at The University of Texas MD Anderson Cancer Center suggests that inflammation may be a crucial catalyst in the very first stages of lung cancer development. By assembling high-resolution cellular and molecular maps of lung tissue before and during tumor emergence,…
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Understanding Immunotherapy Resistance in Kidney Cancer: The Role of Myeloid Cell Signaling
Overview: A New Mechanism Driving Immunotherapy Resistance in Kidney Cancer Immunotherapy has transformed the treatment landscape for advanced renal cell carcinoma (RCC), offering durable responses for some patients. Yet a significant proportion of individuals experience resistance, limiting the long-term effectiveness of immune-based therapies. A landmark study published in Immunity in October 2025 identifies a key…
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Unraveling Immunotherapy Resistance in Kidney Cancer: The Role of Myeloid Cell Signaling
Overview: Immunotherapy and the Challenge in Advanced Kidney Cancer Immunotherapy has transformed treatment for many cancers, including renal cell carcinoma (RCC). Yet a significant subset of patients with advanced RCC experience limited benefit due to intrinsic or acquired resistance. A recent research focus centers on the tumor microenvironment, where immune and myeloid cells communicate in…
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Myeloid-Driven Immunotherapy Resistance in Kidney Cancer: Interferon Signaling Under Scrutiny
Overview: A New Mechanism Behind Immunotherapy Resistance in Kidney Cancer Immunotherapy has transformed the treatment landscape for advanced renal cell carcinoma (RCC), but responses remain inconsistent. A landmark study published in Immunity (October 2025) by researchers including Dana-Farber Cancer Institute’s Eliezer M. Van Allen, MD, identifies a critical role for myeloid cells in shaping resistance…
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Nanoparticle Breakthrough: A New Strategy to Activate the Immune System Against Ovarian Tumors
New Nanoparticles Spark Immune Response Against Ovarian Tumors Researchers are turning to nanotechnology to overcome a long-standing challenge in cancer immunotherapy: how to effectively stimulate the immune system to recognize and destroy ovarian tumors. A new class of nanoparticles is showing promise by delivering immune-activating signals directly to tumor sites and modulating the tumor microenvironment…
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IFITM3-MET Interaction Drives Osimertinib Resistance in EGFR-Mutant NSCLC
Overview: A New Mechanism Behind Osimertinib Resistance in EGFR-Mutant NSCLC Osimertinib has transformed the treatment landscape for patients with EGFR-mutant non-small cell lung cancer (NSCLC). Yet resistance remains a major hurdle. A recent study identifies a non-genetic mechanism: the membrane protein IFITM3 interacts with MET to activate the PI3K-AKT signaling axis, enabling tumor cells to…
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Switching Immune-Cold Tumors to Immune-Hot: A Breakthrough Path to Durable Cancer Immunity
Turning the Tide on Immune-Cold Tumors In a pivotal study published in Nature Immunology, scientists reveal a strategy that could make aggressive, immune-suppressive tumors more vulnerable to the body’s defenses. Funded by the National Cancer Institute/NIH, the research builds on prior work in breast cancer to show that transforming the tumor microenvironment can awaken a…