Tag: TNBC
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LncRNAs and MAPK Signaling in Breast Cancer: Interplay Driving Pathogenesis and Therapy Options
Introduction: The MAPK Landscape in Breast Cancer MAPK signaling is a cornerstone of cellular decision-making, translating external cues into outcomes such as proliferation, differentiation, migration, and survival. In breast cancer, three major MAPK branches—ERK, JNK, and p38—coordinate responses to growth factors, cytokines, and stress signals. While mutations in upstream components frequently hijack this network, noncoding…
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EZH2 Inhibition Blocks TNBC Metastasis and Restores Chromosomal Stability
New findings link EZH2 to chromosomal chaos and metastasis in TNBC Triple-negative breast cancer (TNBC) remains one of the most challenging cancer types to treat due to its aggressive nature and lack of targeted hormones. A groundbreaking preclinical study from Weill Cornell Medicine, published in Cancer Discovery, identifies a surprising driver of TNBC metastasis and…
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New Strategy Targets EZH2 to Block TNBC Metastasis and Restore Chromosomal Stability
Breakthrough in Triple-Negative Breast Cancer: Targeting EZH2 to Halt Metastasis Triple-negative breast cancer (TNBC) remains one of the most aggressive and hard-to-treat forms of breast cancer. A new preclinical study from Weill Cornell Medicine proposes a surprising and hopeful strategy: inhibiting an enzyme called EZH2 to prevent cancer cells from disseminating to distant organs by…