Tag: time-to-event


  • Modeling Strategies for Flexible Estimation of Crude Cumulative Incidence in Long Follow-Ups

    Modeling Strategies for Flexible Estimation of Crude Cumulative Incidence in Long Follow-Ups

    Introduction: Why crude cumulative incidence matters in long follow-ups In clinical studies evaluating therapeutic interventions, overall survival is a well-established endpoint. However, crude cumulative incidence (CCI) offers a direct view of event probabilities when competing risks are present. When follow-up is prolonged, standard methods can misestimate CCI due to time-varying hazards and changing risk profiles.…