Tag: therapy resistance
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Targeting Highly Plastic Cancer Cells: A New Frontier in Combating Progression and Drug Resistance
Understanding cancer cell plasticity Cancer is not a uniform mass of identical cells. Within a tumor, a small subpopulation of cells can exhibit remarkable plasticity—the ability to change their identity and behavior in response to environmental cues. This cellular flexibility enables tumors to adapt, survive, and evolve under therapeutic pressure. Recent research highlights that these…
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Interplay of lncRNAs and MAPK Signaling in Breast Cancer Pathogenesis
Overview: lncRNAs and the MAPK Signaling Web in Breast Cancer Breast cancer pathogenesis is shaped by intricate signaling networks, with MAPK pathways acting as central hubs that govern proliferation, survival, migration, and angiogenesis. Long non-coding RNAs (lncRNAs) have emerged as influential regulators of these cascades, operating as molecular sponges, scaffolds, and downstream effectors. This article…