Tag: Therapeutics
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Aging Spleen Shapes T Cell Health: New Study Reveals Mechanism and Therapies
Understanding the aging immune system As people age, the immune system often becomes less effective, leaving older adults more susceptible to infections and slower to recover. A recent study from the Technion—Israel Institute of Technology Faculty of Biology sheds light on a specific cofactor in this decline: the aging spleen. The researchers describe how changes…
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Research Uncovers Inflammasome’s Role in Male Periodontitis
New Findings Link Inflammasome to Male Periodontitis A recent study from the University of North Carolina at Chapel Hill shines new light on the inflammatory processes behind periodontitis, a leading cause of tooth loss worldwide. The UNC Adams School of Dentistry research identifies a key role for the inflammasome—a multiprotein complex inside immune cells—in driving…
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LassoESM: A New AI-Driven Path to Therapeutic Lasso Peptides
Revealing a new AI tool for lasso peptides In the race to develop novel therapeutics for cancer and infectious diseases, lasso peptides have emerged as a promising class. Their knot-like structures confer remarkable stability and diverse biological activities, making them attractive candidates for future drugs. A collaboration led by the Carl R. Woese Institute for…
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LassoESM: A New AI Tool Accelerating Therapeutic Lasso Peptide Discovery
AI Meets Molecular Biology: The Rise of LassoESM In the race to uncover new therapeutics for cancer and infectious diseases, lasso peptides stand out for their knot-like, highly stable structures and diverse biological activities. A collaboration led by researchers at the Carl R. Woese Institute for Genomic Biology has given the field a powerful new…
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UChicago Scientists Identify CPD Gene Mutation Tied to Deafness and Point to Treatments
Groundbreaking Discovery Links CPD Gene Mutations to Deafness A collaborative team of scientists from the University of Chicago, the University of Miami, and several Turkish institutions has identified a mutation in the CPD gene that is closely linked to a rare form of congenital sensorineural hearing loss (SNHL). The findings, published in the Journal of…
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CPD Gene Mutations Reveal New Path to Rare Congenital Hearing Loss
Introduction: A New Clue in Rare Congenital Hearing Loss A multinational team of researchers has identified mutations in the CPD gene that contribute to a rare form of congenital hearing loss. The findings, published in the Journal of Clinical Investigation, illuminate how a gene long associated with protein modification can also influence the inner ear.…
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CPD Gene Mutations Reveal Cause of Rare Congenital Hearing Loss and Therapeutic Avenues
New Evidence Spots CPD Gene Mutations as a Driver of Congenital Hearing Loss A global team of researchers has identified mutations in the CPD gene as a key factor in a rare form of congenital hearing loss. The study, conducted by scientists from the University of Chicago, the University of Miami, and several Turkish institutions,…
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Global standard for dengue trial outcomes: a new consensus to accelerate therapies
Groundbreaking move in dengue research A landmark publication in The Lancet Infectious Diseases announces the first global standard for measuring outcomes in dengue treatment trials. Co-led by researchers from King’s College London and the University of Oxford, the work represents a concerted effort to harmonize what researchers should measure when testing therapies for dengue fever.…
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Discovery opens up new avenues for treating rotavirus infections
Groundbreaking Insight into Rotavirus Infection Rotavirus remains a leading cause of severe dehydrating diarrhea in infants and young children worldwide, claiming hundreds of thousands of lives annually despite vaccination efforts. In recent years, declining vaccination uptake in some regions has contributed to a troubling rise in cases in the United States. A new study from…
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Mitochondrial DNA Leakage May Fuel Inflammation as We Age—and Targeting It Could Boost Healthy Longevity
Understanding the Link Between Mitochondrial DNA and Inflammation As science shines a light on the cellular processes that drive aging, a growing body of research points to mitochondria—the powerhouses of our cells—as more than just energy producers. A new study from the Max Planck Institute for Biology of Ageing in Germany reveals a molecular mechanism…