Tag: telomerase
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Identification of Novel TERT Promoter Mutations in Chronic Hepatitis B and Their Link to Hepatocellular Carcinoma
Background: Hepatitis B and Liver Cancer Risk Liver cancer remains a major global health challenge, with hepatocellular carcinoma (HCC) being the most common form. Chronic hepatitis B virus (HBV) infection is a well-established driver of HCC, contributing to carcinogenesis through chronic inflammation, liver injury, and genomic instability. In recent years, researchers have turned a spotlight…
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Identification of Novel TERT Promoter Mutations in Chronic Hepatitis B
Introduction Chronic Hepatitis B infection remains a major global health challenge, with a well-established link to hepatocellular carcinoma (HCC). Recent research has turned its attention to the telomerase reverse transcriptase (TERT) promoter, a genomic region that regulates telomerase activity and cellular immortality. While TERT promoter mutations have been documented in various cancers, their role in…
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Telomere Length Inheritance: Why It Matters for Health
Telomeres: what they are and why they shorten Telomeres are protective caps at the ends of chromosomes, made of repetitive DNA and specialized proteins. Each time a cell divides, these caps shorten a little. When telomeres become critically short, cells stop dividing in a state called cellular senescence. This process is linked to chronic inflammation…
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Telomere Inheritance: How Telomere Length Is Passed Down and Why It Matters
Telomeres: The Protective Caps at the End of Chromosomes Telomeres are the protective caps that protect our genetic information, much like aglets guard shoelaces from fraying. Each time a cell divides, these caps shorten a little. When they become critically short, a cell stops dividing in a state called cellular senescence, a process linked to…
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Telomere Length Inheritance and the Parent-of-Origin Effect
Telomeres: The Small Shields at Chromosome Ends Telomeres are the protective caps at chromosome ends, composed of repetitive DNA sequences and protective proteins. Each time a cell divides, these caps shorten, and once they become critically short, the cell halts division in a state called cellular senescence. This natural limit is linked to chronic inflammation…