Tag: survival analysis
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Modeling Strategies for Flexible Estimation of Crude Cumulative Incidence in Long Follow-Ups: Model Choice and Predictive Ability Evaluation
Introduction In clinical studies evaluating therapies for major diseases such as cancer, overall survival (OS) is a gold standard endpoint. Yet OS blends multiple failure causes and can obscure the actual burden of disease- or treatment-related events. In long follow-ups, competing risks (e.g., non-disease death) influence observed outcomes and make crude cumulative incidence (CIF) a…
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Modeling Strategies for Flexible Estimation of Crude Cumulative Incidence in Long Follow-Ups
Introduction: Why crude cumulative incidence matters in long follow-ups In clinical studies evaluating therapeutic interventions, overall survival is a well-established endpoint. However, crude cumulative incidence (CCI) offers a direct view of event probabilities when competing risks are present. When follow-up is prolonged, standard methods can misestimate CCI due to time-varying hazards and changing risk profiles.…