Tag: SUPREMO trial
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SUPREMO Trial: Rethinking Postmastectomy Radiotherapy
Overview: A Shift in Postmastectomy Strategy The international phase 3 SUPREMO trial is reshaping how clinicians treat intermediate-risk early breast cancer (eBC) after mastectomy. The study, officially registered as ISRCTN61145589, investigated whether omitting chest-wall irradiation could maintain survival outcomes while reducing treatment-related toxicity. Historically, postmastectomy radiotherapy (PMRT) has been standard care for various levels of…
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Modern Therapies Challenge Radiation’s Role in Early Breast Cancer Survival
Rethinking Postmastectomy Radiation in Early Breast Cancer New evidence from the international phase 3 SUPREMO trial is prompting clinicians to rethink the standard use of chest-wall irradiation after mastectomy for patients with intermediate-risk early breast cancer (eBC). The study explored whether omitting radiotherapy could maintain survival while reducing treatment-related harms, a question that directly affects…