Tag: STING
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Switching Immune-Cold Tumors to Immune-Hot: A Breakthrough Path to Durable Cancer Immunity
Turning the Tide on Immune-Cold Tumors In a pivotal study published in Nature Immunology, scientists reveal a strategy that could make aggressive, immune-suppressive tumors more vulnerable to the body’s defenses. Funded by the National Cancer Institute/NIH, the research builds on prior work in breast cancer to show that transforming the tumor microenvironment can awaken a…
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Ganoderma lucidum and Liver Health: Protecting the Liver from High-Fat Diet Lipotoxicity
Understanding the Challenge: High-Fat Diets and Liver Health Long-term consumption of high-fat diets (HFD) is known to impose lipotoxic stress on multiple organs, with the liver bearing a heavy burden. As fat accumulates, hepatocytes face metabolic dysfunction, inflammation, and cell injury that can progress to steatosis and liver disease. This emerging research explores not only…
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Switching Immune Cold Tumors to Immune Hot: A Breakthrough in Cancer immunotherapy
Overview: Turning immune-cold tumors into immune-hot targets In a significant advance for cancer immunotherapy, researchers have identified a strategy to reprogram immune-cold tumors—those that typically evade detection—into immune-hot tumors that recruit and coordinate immune cells to attack cancer. The study, recently published in Nature Immunology, builds on decades of work to harness the body’s own…
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Ganoderma lucidum Shields Liver Damage from High-Fat Diets
Overview: High-Fat Diets, Liver Lipotoxicity, and the Search for Protection Long-term consumption of a high-fat diet (HFD) is linked to progressive liver damage, metabolic dysfunction, and fears of nonalcoholic fatty liver disease. In a recent study, researchers investigated how HFD drives lipid accumulation, inflammatory responses, and cellular stress in the liver, and whether Ganoderma lucidum…
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Researchers Discover a Switch that Transforms Immune-Cold Tumors into Immune-Hot, Boosting Cancer Therapy
Transforming Immune-Cold Tumors into Immune-Active Targets Cancer research has long grappled with tumors that evade the body’s defenses. A recent study published in Nature Immunology, backed by the National Cancer Institute/NIH, reports a promising strategy to convert these immune-cold tumors into immune-hot ones. By priming the tumor environment with immune-activating signals, researchers observed a robust,…
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Ganoderma lucidum protects the liver from high-fat diet lipotoxicity: new insights
Background: The challenge of high-fat diet lipotoxicity A sustained high-fat diet (HFD) can drive metabolic derangements that disproportionately affect the liver. Lipotoxicity from excess fatty acids and lipid intermediates promotes hepatic steatosis, liver injury, and inflammation, contributing to metabolic diseases such as non-alcoholic fatty liver disease (NAFLD). Understanding the dynamic effects of HFD on liver…
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Engineered Salmonella therapy delivers immune payloads to combat cancer
Breakthrough in bacterial immunotherapy: ACTM-838 targets solid tumors Solid tumors have long posed a challenge for immunotherapy, often creating an immune-suppressive microenvironment that thwarts even the most advanced treatments. A new study published in Oncotarget (Volume 16, October 6, 2025) introduces ACTM-838, a novel systemically delivered bacterial immunotherapy designed to enrich in solid tumors and…
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Engineered Salmonella Therapy Delivers Immune Payloads to Fight Cancer
New Bacterial Immunotherapy Targets Solid Tumors Researchers have unveiled ACTM-838, a novel, systemically delivered bacterial immunotherapy designed to enrich solid tumors with immune-stimulating payloads. Published in Volume 16 of Oncotarget on October 6, 2025, the study demonstrates how a specially engineered Salmonella Typhimurium strain can safely localize to tumors and deliver potent immune activators directly…