Tag: single-chromosome sequencing
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Single-Chromosome Sequencing in Human Cancers: Key Genes and Insights
Introduction: A focused lens on cancer genomics The field of cancer genetics is rapidly evolving, with researchers seeking methods that offer high-resolution insights while managing complexity. Single-chromosome sequencing represents a focused approach that targets individual chromosomes to reveal mutations, structural variations, and regulatory changes that drive tumor behavior. This review by Brian Tait, Chief Scientific…
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Single-Chromosome Sequencing in Human Cancers: A Window into Gene-Specific Tumor Biology
Introduction: Why Focus on a Single Chromosome? Cancer genetics has traditionally relied on bulk genome analyses, which average signals across millions of cells. While informative, this approach can obscure rare but functionally critical events occurring on individual chromosomes. The idea of single-chromosome sequencing—an approach that isolates and analyzes one chromosome at a time—offers a rare…
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Single-Chromosome Sequencing in Human Cancers: Advancing Precision Oncology
Introduction: Why Focus on Single-Chromosome Sequencing? In cancer genetics, the ability to map alterations at the level of a single chromosome offers a focused lens on genomic instability, chromosomal rearrangements, and gene dosage effects. Single-chromosome sequencing (SCS) enables researchers to isolate and analyze one chromosome at a time, reducing complexity from the entire genome and…