Tag: signal transduction
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Decoding Sepsis Signaling and Metabolic Dysregulation
Introduction: The Signaling Web Behind Sepsis Sepsis is a life-threatening syndrome driven by dysregulated immune responses and widespread metabolic disruption. Modern research reveals that sepsis emerges from an intricate network of signaling pathways that control inflammation and cellular energy. By decoding these networks—rather than focusing on a single target—we can better understand disease progression and…
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LncRNAs and MAPK Signaling in Breast Cancer: Interplay Driving Pathogenesis and Therapy Options
Introduction: The MAPK Landscape in Breast Cancer MAPK signaling is a cornerstone of cellular decision-making, translating external cues into outcomes such as proliferation, differentiation, migration, and survival. In breast cancer, three major MAPK branches—ERK, JNK, and p38—coordinate responses to growth factors, cytokines, and stress signals. While mutations in upstream components frequently hijack this network, noncoding…