Tag: signal transduction
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New Fluorescent Markers Reveal Dynamic Cell Communication
Unlocking Real-Time Cell Conversation Living tissues are made up of countless cells that continuously exchange signals to coordinate functions from development to daily maintenance. A team of researchers in Japan has developed a groundbreaking set of fluorescent markers that illuminate when and how cells touch each other, offering a window into the dynamic conversations that…
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How Structural Findings Explain Why GPCR Ligands Trigger Different Activation Levels
Understanding GPCRs and Their Ligands G-protein coupled receptors (GPCRs) are essential players in cellular communication. They sit on the cell surface and respond to a diverse set of ligands—ranging from tiny ions to large proteins—that bind to the receptor and initiate intracellular signaling. The resulting response is mediated primarily through heterotrimeric G proteins, which translate…
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Decoding Sepsis Signaling and Metabolic Dysregulation
Introduction: The Signaling Web Behind Sepsis Sepsis is a life-threatening syndrome driven by dysregulated immune responses and widespread metabolic disruption. Modern research reveals that sepsis emerges from an intricate network of signaling pathways that control inflammation and cellular energy. By decoding these networks—rather than focusing on a single target—we can better understand disease progression and…
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LncRNAs and MAPK Signaling in Breast Cancer: Interplay Driving Pathogenesis and Therapy Options
Introduction: The MAPK Landscape in Breast Cancer MAPK signaling is a cornerstone of cellular decision-making, translating external cues into outcomes such as proliferation, differentiation, migration, and survival. In breast cancer, three major MAPK branches—ERK, JNK, and p38—coordinate responses to growth factors, cytokines, and stress signals. While mutations in upstream components frequently hijack this network, noncoding…