Tag: Redox Biology
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The GOE and the Emergence of Aerobic Bacteria: Tracing the Rise of Oxygen-Using Life
Intro: Oxygen and a Turning Point in Life on Earth The Great Oxygenation Event (GOE) marks a turning point in Earth’s history when atmospheric oxygen began to accumulate, fundamentally reshaping biological possibilities. The transition from strictly anaerobic metabolism to aerobic respiration enabled organisms to harvest far more energy from glucose, fueling complexity, diversification, and the…
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The Dual Role of SLC7A11 in Colorectal Cancer Ferroptosis: From Molecules to Therapies
Understanding Ferroptosis and SLC7A11 Ferroptosis is a regulated form of cell death driven by iron-dependent lipid peroxidation. In colorectal cancer (CRC), ferroptosis represents a promising avenue to overcome resistance to conventional therapies. Central to this process is SLC7A11, a component of the cystine/glutamate antiporter system Xc–, which imports cystine into cells in exchange for glutamate.…