Tag: randomized trial
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Colistin-Based Strategies Against CRE: Insights from the AIDA Randomized Trial on Acquisition and Molecular Traits after Monotherapy vs. Colistin-Meropenem Therapy
Overview: Why the AIDA Trial Matters for CRE Management Carbapenem-resistant Enterobacterales (CRE) pose a critical challenge in modern medicine, limiting effective treatment options and driving higher mortality. In the ongoing effort to optimize therapy, clinicians frequently employ colistin-based regimens, either as monotherapy or in combination with meropenem. The AIDA randomized trial investigates how these regimens…
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Stereotactic Body Radiation Therapy in Inoperable PDAC: The TORPEDO Phase II Randomised Trial
Understanding the challenge of inoperable pancreatic cancer Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive solid tumors, with limited treatment options for patients whose disease is non-metastatic but inoperable. For these individuals, conventional treatment often focuses on systemic therapy and palliative care, aiming to control symptoms and extend survival without compromising quality of…
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Should I Play or Should I Watch? The Impact of Active vs Passive Distraction on Pediatric Procedural Pain
Introduction: Reducing distress in the pediatric procedure room Invasive procedures like venipuncture and peripheral intravenous cannulation are routine yet distressing for young children. Pain, fear, and anxiety not only affect the immediate experience but can also influence future medical encounters, cooperation, and long-term emotional well-being. Distraction techniques—non-pharmacological, low-risk approaches—are increasingly recommended to complement standard care.…
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Pecha Kucha BLS Training Boosts Knowledge and Skills in Health Services Students
Overview Basic Life Support (BLS) training is a cornerstone of emergency medical education. Despite its importance, traditional teaching methods can leave gaps in knowledge retention and practical readiness. A randomized controlled trial explored an innovative approach: delivering BLS training through the Pecha Kucha (PK) presentation format. PK, a concise, image-rich method comprising 20 slides shown…
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PREDIABETEXT: A Digital Intervention Trial to Prevent Type 2 Diabetes in Primary Care
Overview: A Digital Approach to Prediabetes Prevention Prediabetes affects millions worldwide and poses a clear risk for progression to type 2 diabetes mellitus (T2DM). In Mallorca, Spain, researchers tested a multifaceted digital intervention called PREDIABETEXT in a real-world primary care setting. The trial explored whether a low-to-moderate intensity program, delivered mainly through SMS messages and…
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A Multifaceted Digital Intervention for Prediabetes Prevention in Primary Care: Insights from the PREDIABETEXT Trial
Introduction: A Global Challenge in Prediabetes Prediabetes affects hundreds of millions worldwide, with rising prevalence driven by urbanization, lifestyle changes, and aging populations. While lifestyle modification programs have shown strong efficacy at reducing diabetes risk, real-world uptake remains a hurdle. PREDIABETEXT (Prediabetes Text Message Digital Intervention for the Prevention of Type 2 Diabetes Mellitus) represents…
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Testing Theory-Enhanced Messaging to Promote COVID-19 Vaccination Among Adults: An RCT Analysis
Overview Public health campaigns continue to seek effective ways to increase COVID-19 vaccination among adults. A recent randomized controlled trial tested two theory-informed messaging approaches—attitudinal inoculation and cognitive behavioral therapy (CBT) kernel messaging—against standard public health messaging to see which could elevate vaccine uptake or readiness. The study focused on adults in the United States…
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Azelastine Nasal Spray: A Potential Shield Against COVID-19 and Rhinovirus
Introduction: A Promising Approach in Respiratory Virus Prevention Azelastine nasal spray, long used to treat allergic rhinitis, is being explored as a potential preventive tool against respiratory viruses, including SARS-CoV-2. Recent findings from a phase II randomized trial published in JAMA Internal Medicine indicate that intranasal azelastine may lower the rate of SARS-CoV-2 infections and…
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Preventing Skin Cancer With a Specific Supplement
Overview: Can a supplement aid skin cancer prevention? Skin cancer remains a rising global health concern, underscoring the importance of preventive strategies beyond daily sun protection. A recent study highlighted in JAMA Dermatology (September 2025) examined whether a specific dietary supplement could influence the likelihood of developing skin cancer. While the findings are intriguing, they…