Tag: Radiation Therapy
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Treating Head and Neck Squamous Cell Carcinoma with Intratumoral Bacteria: New Hope from Radiation and Chemotherapy Advances
Understanding the Breakthrough Head and neck squamous cell carcinoma (HNSCC) is a challenging cancer type, often requiring aggressive radiation and chemotherapy regimens. Recent research, including an international multicenter trial led by MSK radiation oncologist Dr. Nancy Lee, has explored a provocative idea: bacteria residing inside tumors can impact how cancer responds to standard treatments. This…
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Treatment for Head and Neck Squamous Cell Carcinoma Affected by Bacteria Inside the Tumors: New Insights from MSK-LED Trial
Understanding intratumoral bacteria in head and neck cancer Head and neck squamous cell carcinoma (HNSCC) is a challenging disease that often requires a combination of radiation and chemotherapy. Recently, scientists have begun investigating an unexpected factor that could influence treatment outcomes: bacteria living inside tumors. This intratumoral microbiome may shape how tumors respond to therapy,…
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Intratumoral Bacteria and the Future of Head and Neck Squamous Cell Carcinoma Treatment: Insights from a Pioneering Trial
Understanding the Role of Intratumoral Bacteria in Head and Neck Squamous Cell Carcinoma Head and neck squamous cell carcinoma (HNSCC) remains a challenging cancer to treat, with outcomes closely tied to tumor biology and the surrounding microenvironment. A growing area of research focuses on the microbiome that resides within tumors — the intratumoral bacteria. Recent…
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SUPREMO Trial: Rethinking Postmastectomy Radiotherapy
Overview: A Shift in Postmastectomy Strategy The international phase 3 SUPREMO trial is reshaping how clinicians treat intermediate-risk early breast cancer (eBC) after mastectomy. The study, officially registered as ISRCTN61145589, investigated whether omitting chest-wall irradiation could maintain survival outcomes while reducing treatment-related toxicity. Historically, postmastectomy radiotherapy (PMRT) has been standard care for various levels of…
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Modern Therapies Challenge Radiation’s Role in Early Breast Cancer Survival
Rethinking Postmastectomy Radiation in Early Breast Cancer New evidence from the international phase 3 SUPREMO trial is prompting clinicians to rethink the standard use of chest-wall irradiation after mastectomy for patients with intermediate-risk early breast cancer (eBC). The study explored whether omitting radiotherapy could maintain survival while reducing treatment-related harms, a question that directly affects…
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Breast Cancer: Radiation May Be Unnecessary for Many Patients
New findings question the routine use of radiation in early breast cancer Radiation therapy has long been a cornerstone of breast cancer treatment, helping to reduce local recurrence after surgery. In recent years, however, many doctors have begun reevaluating its role for patients with early-stage disease. Advances in imaging, tumor biology, and systemic therapies have…




