Tag: psychiatry
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Social capital and evidence-based orientation shaping psychiatrists’ views on antipsychotic polypharmacy in schizophrenia
Understanding the debate: Antipsychotic polypharmacy in schizophrenia Antipsychotic polypharmacy (APP) — prescribing more than one antipsychotic medication simultaneously — remains a contentious practice in schizophrenia care. While some clinicians view APP as a necessary strategy to manage treatment-resistant symptoms or to augment partial responses, others warn of limited evidence, increased adverse events, and higher costs.…
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Social Capital and Evidence-Based Orientation Shape Psychiatrists’ Views on Antipsychotic Polypharmacy in Schizophrenia
Introduction Antipsychotic polypharmacy (APP) remains a contentious practice in the treatment of schizophrenia. While some clinicians advocate for combining antipsychotics to address persistent symptoms or treatment resistance, others warn of increased side effects, drug interactions, and uncertain efficacy. Emerging research suggests that a psychiatrist’s social capital—the networks, alliances, and professional influence within their clinical and…
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How Social Capital and Evidence-Based Orientation Shape Psychiatrists’ Views on Antipsychotic Polypharmacy in Schizophrenia
Overview: Why Attitudes Toward Antipsychotic Polypharmacy Matter Antipsychotic polypharmacy (APP) — the concomitant use of two or more antipsychotic drugs — remains a contentious issue in schizophrenia management. While some guidelines advise caution and careful monitoring, others acknowledge tailored approaches when monotherapy fails. Understanding what shapes psychiatrists’ attitudes toward APP is essential because clinician preferences…
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The Divided Mind by Edward Bullmore: Do We Now Know What Causes Schizophrenia?
Introduction: A timely re-examination Edward Bullmore’s The Divided Mind takes readers on a rigorous tour of what we know—and what remains stubbornly uncertain—about the origins of schizophrenia. Building on decades of neurobiology and clinical insight, the book surveys brain networks, genetics, and early-life experiences to ask a simple yet profound question: do we truly understand…
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The Divided Mind review: Do we now know what causes schizophrenia?
Introduction: A timely question in a divided field Edward Bullmore’s The Divided Mind surveys the tangled terrain of schizophrenia’s origins. In a field long haunted by competing explanations—biological vulnerability, environmental stressors, and the fragile interpretations of the patient’s subjective experience—Bullmore threads a cautious path between determinism and uncertainty. The central question he revisits is deceptively…
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The Divided Mind review: Do we finally know what causes schizophrenia?
Introduction: A timely revisit of a stubborn question Edward Bullmore’s The Divided Mind revisits one of psychiatry’s most persistent puzzles: what actually causes schizophrenia? Building on decades of research, including the provocative Rosenhan experiment of 1973, Bullmore weaves together biology, psychology, and social context to ask whether a single root cause exists—or whether the disorder…
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Scientists Pinpoint Brain Cells That Drive Anxiety in Mice
Overview: A breakthrough in the anxiety puzzle Anxiety disorders affect millions and remain one of the most common mental health challenges in the United States. While therapies and medications help many, scientists have long sought to understand the cellular roots of anxiety. A new study in mice provides a sharper map of the brain cells…
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New Frontiers in Treating Treatment-Resistant Depression: Vagus Nerve Stimulation and Beyond
Overview: The Rising Need for Neuromodulation in MDD Major depressive disorder (MDD) remains a global health challenge, with a significant subset of patients — up to 35% — not responding after four or more standard treatment trials. In the face of this treatment resistance, researchers and clinicians are turning to neuromodulation as a viable alternative…
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Multi-System Biomarkers for Suicide Risk in MDD: Erythroid, Inflammation, and Metabolism
Introduction: The Need for Multi-System Biomarkers in MDD Major Depressive Disorder (MDD) remains a leading cause of disability worldwide, with suicide risk representing a critical and urgent challenge for clinicians. Traditional risk assessment often relies on clinical history and self-reported symptoms, which can miss biologically meaningful signals. Emerging research points to a multi-system model of…
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Multi-system Biomarkers for Suicide Risk in Major Depressive Disorder: Erythroid, Inflammatory, and Metabolic Integration
Introduction: The Need for Multi-system Biomarkers in MDD Major Depressive Disorder (MDD) remains a leading cause of disability worldwide, with suicide risk representing a critical and urgent concern. Traditional risk assessment relies heavily on clinical history and self-reported symptoms, which can fail to capture dynamic biological processes that contribute to suicidality. Emerging evidence suggests that…