Tag: proteostasis
-
When Proteins Overcheck: How Overactive Cleanup Disrupts Nuclear Pores in Neurodegenerative Disease
Understanding the link between proteostasis and the nuclear pore Proteostasis, or protein quality control, is essential for cellular health. In neurons, a delicate balance exists to fold, refold, and degrade proteins as needed. When this system becomes overactive or dysregulated, it can misfire against the cell’s own components. One striking target is the nuclear pore…
-
Overactive Protein Cleanup Disrupts Nuclear Pores in Neurodegenerative Disease
New insights into the proteostasis puzzle in neurodegenerative disease Scientists are piecing together how cellular cleanup crews, tasked with maintaining protein quality, can sometimes backfire and threaten essential structures in the cell. In particular, excessive or misregulated protein degradation processes appear to disrupt nuclear pores, the gateways that regulate traffic between the nucleus and the…
-
Research with bite – Greenland shark offers clues to preventing age-related vision loss
Unlocking a Mystery from the Deep In a field where aging is as much a mystery as the ocean itself, new research dives into the biology of the Greenland shark to uncover clues about preserving vision as we grow older. Led by Associate Professor Dorota Skowronska-Krawczyk from the University of California, the study highlights how…
-
Calcium Signaling: A Key Regulator of Protein Quality in the Endoplasmic Reticulum
Introduction: Calcium’s Pivotal Role in the ER Calcium (Ca2+) is more than a universal messenger in the cell; it is a critical regulator of how proteins are folded and quality-checked inside the endoplasmic reticulum (ER). The ER is the cellular workshop where most secretory and membrane proteins acquire their correct structure before being dispatched to…