Tag: protein quality control
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CUL5: The Brain’s Garbage Collector That Clears Toxic Tau and Shields Neurons
New Discovery: A Brain Cleanup Crew Called CUL5 Scientists at the University of California, San Francisco, have identified a cellular mechanism that acts like a waste collector in the brain. The protein CUL5 appears to help neurons dispose of toxic tau clumps, which are a hallmark of several neurodegenerative diseases and a major driver of…
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When Proteins Overcheck: How Overactive Cleanup Disrupts Nuclear Pores in Neurodegenerative Disease
Understanding the link between proteostasis and the nuclear pore Proteostasis, or protein quality control, is essential for cellular health. In neurons, a delicate balance exists to fold, refold, and degrade proteins as needed. When this system becomes overactive or dysregulated, it can misfire against the cell’s own components. One striking target is the nuclear pore…