Tag: protein design
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Computational Strategy Illuminates Membrane Protein Function
New Computational Approach Sheds Light on Membrane Protein Architecture Membrane proteins sit at the critical interface of the cell, governing substance transport, signal transduction, reaction acceleration, and cell–cell interactions. When these proteins misbehave, disease can follow, making them prime targets for therapies. Yet studying their behavior in the lipid bilayer has long posed a challenge.…
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New Computer-Driven Insights Reveal How Protein Patterns Shape Cell Membranes
Unveiling the Hidden Architecture of Membrane Proteins Membrane proteins are essential gatekeepers and signal transmitters in the body, guiding what enters and exits cells, orchestrating chemical reactions, and helping tissues adhere. When these proteins malfunction, diseases including cancer can arise. Despite their importance, studying them has long been a challenge because they reside in the…
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Researchers Unveil How a Membrane Protein Motif Stabilizes Protein Architecture
New Insights into Membrane Protein Architecture Scientists at Scripps Research have unlocked fresh understanding of how membrane proteins—crucial players in transport, signaling, and cellular adhesion—achieve and maintain their complex shapes within the cell’s lipid envelope. Published in the Proceedings of the National Academy of Sciences on October 7, 2025, the study presents a computer-guided approach…
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Gly-X6-Gly Motif Reveals Membrane Protein Rules in Cells
Unraveling the Mysteries of Membrane Proteins Membrane proteins are essential gatekeepers of the cell, orchestrating substance transport, signal transduction, and intercellular adhesion. When their function goes awry, diseases such as cancer can arise, making these proteins prime targets for therapies. Yet studying membrane proteins is notoriously difficult because their lipid surroundings help them hide their…