Tag: precision oncology
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Oncomarkers Awareness Day: Advancing Precision Oncology Through Biomarker Science
Introduction: A Global Day for Biomarker Science Oncomarkers Awareness Day, first observed on November 13, 2025, marks a milestone in the cancer care landscape. This international observance highlights how biomarkers—the measurable indicators of biological processes—are shaping precision oncology. By providing richer diagnostic insights, guiding therapy choices, and monitoring treatment response, biomarkers are helping clinicians tailor…
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New Nanoparticles Stimulate the Immune System to Attack Ovarian Tumors
Reframing Immunotherapy for Ovarian Cancer Immunotherapy has transformed cancer treatment by empowering the body’s own defender — the immune system — to recognize and destroy tumor cells. Yet ovarian cancer has proved streaky ground for many immunotherapies, with tumors often adept at cloaking themselves from immune detection. Recent advances, however, suggest that nanoscale delivery systems…
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Single-Chromosome Sequencing in Human Cancers: Key Genes and Insights
Introduction: A focused lens on cancer genomics The field of cancer genetics is rapidly evolving, with researchers seeking methods that offer high-resolution insights while managing complexity. Single-chromosome sequencing represents a focused approach that targets individual chromosomes to reveal mutations, structural variations, and regulatory changes that drive tumor behavior. This review by Brian Tait, Chief Scientific…
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Single-Chromosome Sequencing in Human Cancers: A Window into Gene-Specific Tumor Biology
Introduction: Why Focus on a Single Chromosome? Cancer genetics has traditionally relied on bulk genome analyses, which average signals across millions of cells. While informative, this approach can obscure rare but functionally critical events occurring on individual chromosomes. The idea of single-chromosome sequencing—an approach that isolates and analyzes one chromosome at a time—offers a rare…
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Single-Chromosome Sequencing in Human Cancers: Advancing Precision Oncology
Introduction: Why Focus on Single-Chromosome Sequencing? In cancer genetics, the ability to map alterations at the level of a single chromosome offers a focused lens on genomic instability, chromosomal rearrangements, and gene dosage effects. Single-chromosome sequencing (SCS) enables researchers to isolate and analyze one chromosome at a time, reducing complexity from the entire genome and…
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Advancing Awareness and Innovation in Invasive Lobular Breast Cancer: Lessons from a Fred Hutch Event
Global Lobular Breast Cancer Day shines spotlight on ILC challenges and breakthroughs Last week, invasive lobular breast cancer (ILC) patients and their care teams gathered at Fred Hutch Cancer Center for a focused two-hour program. The event, held on October 15 to mark Global Lobular Breast Cancer Awareness Day, brought patient stories, epidemiological insights, and…
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Changing the Narrative: Calgary’s New Sarcoma Breakthroughs Through iSARP
Changing the Narrative in Calgary’s Cancer Care When Dr. Michael Monument returned to his hometown of Calgary in 2014 after a fellowship at the University of Utah, he faced a challenge that would shape the next decade of cancer research in the city. Sarcoma, a relatively rare but devastating group of bone and soft tissue…
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Changing the narrative: Calgary’s new frontier in sarcoma therapy
Changing the Narrative: Calgary’s Leap into Sarcoma Innovation When Dr. Michael Monument returned to his hometown of Calgary in 2014 after a fellowship at the University of Utah, colleagues warned that the city might not be a natural home for sarcoma research. Sarcoma—an often rare cancer that targets bone and soft tissues and frequently affects…
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Changing the Narrative: How Calgary’s iSARP Is Redefining Sarcoma Therapy
Changing the Narrative in Calgary’s Medical Landscape When Dr. Michael Monument returned to his hometown of Calgary in 2014 after a fellowship at the University of Utah, colleagues warned him that the city might not be the best place to pursue sarcoma research. Sarcoma, a relatively rare family of bone and soft tissue tumors that…
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Personalized TAMENDOX Therapy Boosts Tamoxifen Effectiveness in Early Breast Cancer
Introduction: A new twist in tamoxifen treatment Breast cancer remains the most commonly diagnosed cancer among women worldwide. In a decisive step toward more effective hormone therapy, the Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology (IKP) has unveiled TAMENDOX, a personalized treatment strategy designed to optimize tamoxifen’s impact for individual patients. This multicenter clinical study…