Tag: pharmacology
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Opioid receptors in motion: new clues for safer painkillers
Understanding the moving target: mu-opioid receptors For decades, scientists have known that opioids relieve pain by binding to mu-opioid receptors in the brain. These molecular switches, when activated, set off a cascade of signals that dull the perception of pain. But the exact sequence of events inside the receptor remained murky. A recent wave of…
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Personalized TAMENDOX Therapy Boosts Tamoxifen Effectiveness in Early Breast Cancer
Introduction: A new twist in tamoxifen treatment Breast cancer remains the most commonly diagnosed cancer among women worldwide. In a decisive step toward more effective hormone therapy, the Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology (IKP) has unveiled TAMENDOX, a personalized treatment strategy designed to optimize tamoxifen’s impact for individual patients. This multicenter clinical study…
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New Personalized Therapy Boosts Tamoxifen Effectiveness in Breast Cancer Patients
Overview Breast cancer remains the most common cancer among women worldwide. Recent advances from the Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology (IKP) introduce a new personalized therapy, TAMENDOX, designed to tailor hormone treatment to individual patients. The goal is to improve the effectiveness of tamoxifen, a long-standing drug used to treat hormone-dependent breast cancer,…
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New Class of Painkillers Aims to Ease Pain Without Suppressing Inflammation
Rethinking Pain Relief: A Targeted Approach Current painkillers, notably non-steroidal anti-inflammatory drugs (NSAIDs), fight pain by dampening inflammation. While effective, this approach can delay healing and increase the risk of side effects affecting the heart, stomach, kidneys, and liver. A new line of research from the University of Florence promises a different path: severing the…
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New Painkillers Could Separate Pain Relief from Inflammation: A Potential Breakthrough
Rewriting Pain Management: A New Strategy Emerges Current non-steroidal anti-inflammatory drugs (NSAIDs) are effective at easing pain by blocking prostaglandins — chemicals involved in inflammation. While this helps reduce discomfort, it can also hinder the body’s healing processes and bring a range of side effects, from stomach issues to heart and kidney risks. A recent…
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New Painkillers Target Pain Without Blocking Healthy Inflammation
Overview: A Shift in Pain Management Current painkillers, especially non-steroidal anti-inflammatory drugs (NSAIDs), are effective at dulling pain but often come with a trade-off: they blunt inflammation, a critical part of the body’s healing process. A new line of research conducted by pharmacologists and clinicians from the University of Florence in Italy investigates a strategy…
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Older Adults in Nursing Homes Face Higher Seizure Risk With Tramodol and Some Antidepressants
New Findings on Drug Interactions in Senior Care A study published on October 8, 2025, in Neurology®, the medical journal of the American Academy of Neurology, reports a modest but meaningful link between taking tramadol for pain and certain antidepressants that inhibit the CYP2D6 enzyme in older adults living in nursing homes. The researchers found…