Tag: PD-L1 blockade


  • Engineered CAR T Cells Target Solid Tumors with IL-12 PD-L1 Fusion

    Engineered CAR T Cells Target Solid Tumors with IL-12 PD-L1 Fusion

    A new approach targets solid tumors Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment landscape for certain blood cancers, but solid tumors—such as prostate, breast, lung, and ovarian cancers—have remained stubborn hurdles. A collaboration between USC Norris Comprehensive Cancer Center and City of Hope has yielded a promising solution: engineering CAR T…