Tag: Pancreatic Cancer
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Stereotactic Body Radiation Therapy in Inoperable PDAC: The TORPEDO Phase II Randomised Trial
Understanding the challenge of inoperable pancreatic cancer Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive solid tumors, with limited treatment options for patients whose disease is non-metastatic but inoperable. For these individuals, conventional treatment often focuses on systemic therapy and palliative care, aiming to control symptoms and extend survival without compromising quality of…
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Stereotactic Body Radiation Therapy in Inoperable Pancreatic Cancer: Insights from the TORPEDO Phase II Randomised Trial
Overview: The TORPEDO Trial and the Challenge of PDAC Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers, with many patients presenting with tumors that are inoperable or unsuitable for conventional curative surgery. In this context, the TORPEDO trial investigates the potential of stereotactic body radiation therapy (SBRT) as a treatment option to…
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Stereotactic body radiation therapy and the TORPEDO trial: A new approach for inoperable pancreatic cancer
Overview: SBRT as a potential option for inoperable PDAC Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging cancers to treat, especially when surgical options are off the table. For patients with non-metastasized yet inoperable disease, there is a critical need for effective, well-tolerated therapies. The TORPEDO trial investigates stereotactic body radiation therapy (SBRT)…
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How 3D Culture Environments Shape Spheroid Morphology, Drug Response, and Invasion in Pancreatic Cancer Cells
Introduction Pancreatic cancer remains a formidable challenge, with 3D cell culture offering a more physiologically relevant model than traditional 2D systems. This study compares how two common scaffold-free 3D platforms— Poly(2-hydroxyethyl methacrylate) (Poly-HEMA or PH) coated plates and ultra-low attachment (ULA) plates—influence spheroid formation, drug sensitivity to gemcitabine, and invasion dynamics in three pancreatic cancer…
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3D Culture Environments Shape Pancreatic Cancer Spheroids
Introduction Three-dimensional (3D) cell culture models are increasingly used to study pancreatic cancer (PCa) because they better mimic the tumor microenvironment than traditional 2D systems. This article reviews how two commonly used scaffold-free 3D platforms—poly(2-hydroxyethyl methacrylate) (PH)-coated plates and ultra-low attachment (ULA) plates—shape spheroid morphology, drug sensitivity, and invasion across PCa cell lines. By comparing…
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Platform-Driven Spheroid Dynamics: How 3D Culture Environments Shape Pancreatic Cancer Behavior
Introduction: Why the Culture Environment Matters in Pancreatic Cancer Research Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers, partly due to its complex microenvironment and resistance to chemotherapy. Traditional 2D cultures fail to capture the 3D architecture and mechanical cues that influence tumor cell behavior. In this study, researchers compared two common…
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Biologic Sex and Obesity Shape Post-Surgical Outcomes in Pancreatic Cancer Study
Overview: How Sex and Obesity Interact in Pancreatic Cancer Surgery Obesity is an escalating global health issue, intertwined with cancer risk and outcomes. A new observational study published in Cancer examines how biologic sex and obesity together shape liver recurrence and overall survival (OS) in patients who underwent upfront surgical resection for pancreatic ductal adenocarcinoma…
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Biologic Sex and Obesity Influence Post-Surgical Outcomes in Pancreatic Cancer, Study Finds
Overview: A Novel Look at Sex, Obesity, and Pancreatic Cancer Outcomes A recent observational study published in Cancer highlights how biologic sex and obesity may shape liver recurrence and overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC) who undergo upfront surgical resection. Analyzing a large cohort treated at Memorial Sloan Kettering Cancer Center…
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IIT-Madras launches cancer genome and tissue bank to advance India’s precision oncology
Revolutionizing cancer care in India Cancer remains a leading global killer, and India faces a rising burden that calls for therapies tailored to its diverse population. IIT-Madras is answering that call with a pioneering cancer genome and tissue bank. The initiative aims to collect and study thousands of tumor samples, enabling researchers to test therapies…
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IIT-Madras Launches India’s Cancer Genome and Tissue Bank
IIT-Madras launches a cancer genome and tissue bank India is witnessing a bold step forward in cancer research as the Indian Institute of Technology Madras announces a cancer genome and tissue bank designed to power personalized therapy. The initiative, supported by the Bharat Cancer Genome Atlas, aims to translate genomic insights into precise, affordable care…