Tag: NMDA receptor
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Cryo-EM Maps Find Autoantibody Hotspots on NMDA Receptors
New insights into anti-NMDAR encephalitis Researchers have long sought to understand why the brain’s immune system sometimes attacks the N-methyl-D-aspartate receptor (NMDAR), triggering a dangerous condition known as autoimmune encephalitis or “Brain on Fire.” A recent study published in Science Advances uses high-resolution Cryo-Electron Microscopy (Cryo-EM) to map where autoantibodies latch onto NMDA receptors. The…
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Cryo-EM Maps Autoantibody Hotspots on NMDA Receptors in Autoimmune Encephalitis
New Cryo-EM insights reveal antibody hotspots on NMDA receptors Researchers have leveraged cutting-edge Cryo-Electron Microscopy (Cryo-EM) to pinpoint where autoantibodies most often target NMDA receptors in anti-NMDAR encephalitis. This autoimmune condition, often described in public health circles as “Brain on Fire,” arises when the body’s immune system mistakenly attacks NMDA receptors in the brain, disrupting…
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Cryo-EM Maps Spotlight Autoantibody Hotspots on NMDA Receptors for Anti-NMDAR Encephalitis Therapies
New Insights into Anti-NMDAR Encephalitis Autoimmune encephalitis linked to anti-NMDA receptor (NMDAR) antibodies has earned the nickname “Brain on Fire” for its dramatic neuropsychiatric symptoms and rapid progression. A groundbreaking study published in Science Advances leverages cryo-electron microscopy (cryo-EM) to map where autoantibodies most often bind on the NMDAR complex. The findings offer a clearer…