Tag: NF-κB
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Ganoderma lucidum and Liver Health: Protecting the Liver from High-Fat Diet Lipotoxicity
Understanding the Challenge: High-Fat Diets and Liver Health Long-term consumption of high-fat diets (HFD) is known to impose lipotoxic stress on multiple organs, with the liver bearing a heavy burden. As fat accumulates, hepatocytes face metabolic dysfunction, inflammation, and cell injury that can progress to steatosis and liver disease. This emerging research explores not only…
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Ganoderma lucidum Shields Liver Damage from High-Fat Diets
Overview: High-Fat Diets, Liver Lipotoxicity, and the Search for Protection Long-term consumption of a high-fat diet (HFD) is linked to progressive liver damage, metabolic dysfunction, and fears of nonalcoholic fatty liver disease. In a recent study, researchers investigated how HFD drives lipid accumulation, inflammatory responses, and cellular stress in the liver, and whether Ganoderma lucidum…
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Ganoderma lucidum protects the liver from high-fat diet lipotoxicity: new insights
Background: The challenge of high-fat diet lipotoxicity A sustained high-fat diet (HFD) can drive metabolic derangements that disproportionately affect the liver. Lipotoxicity from excess fatty acids and lipid intermediates promotes hepatic steatosis, liver injury, and inflammation, contributing to metabolic diseases such as non-alcoholic fatty liver disease (NAFLD). Understanding the dynamic effects of HFD on liver…
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Decoding Sepsis Signaling and Metabolic Dysregulation
Introduction: The Signaling Web Behind Sepsis Sepsis is a life-threatening syndrome driven by dysregulated immune responses and widespread metabolic disruption. Modern research reveals that sepsis emerges from an intricate network of signaling pathways that control inflammation and cellular energy. By decoding these networks—rather than focusing on a single target—we can better understand disease progression and…
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Decoding Signaling Networks and Metabolic Dysregulation in Sepsis: Toward Dynamic, Multi-Target Therapies
Introduction: Sepsis as a Signaling and Metabolic Challenge Sepsis is a complex, life-threatening syndrome driven by dysregulated immune responses, systemic inflammation, and widespread metabolic disruption. Traditional treatments, centered on antibiotics and early goal-directed therapy, often fall short due to the dynamic and heterogeneous nature of the disease. A growing body of research points to a…
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Decoding Signaling Networks and Metabolic Dysregulation in Sepsis
Understanding Sepsis: A Web of Signaling and Metabolism Sepsis is a life-threatening syndrome arising from infection that triggers a dysregulated immune response and widespread organ dysfunction. Modern research paints a picture of sepsis not as a single pathway anomaly but as a complex network of interlocking signaling cascades and metabolic changes. Central to this network…