Tag: neutrophils
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Hypoxia Reprograms Neutrophils: Long-Term Immune Impact
Hypoxia and the immune system: a surprising link Scientists are uncovering how low oxygen levels, or hypoxia, can do more than cause immediate trouble breathing. New research suggests that hypoxia can reprogram a key group of immune cells—neutrophils—by changing the way their genetic material is packaged. This finding points to a lasting impact on the…
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Hypoxia Alters Neutrophil DNA, Weakening Infection Defense
New findings link low oxygen to lasting changes in neutrophils Hypoxia, or low blood oxygen, is not only a short-term stress on the body. New research shows it can reprogram a crucial immune cell—neutrophils—by altering the way their genetic material is packaged and read. This discovery helps explain why people who recover from severe lung…
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Prognostic Value of Low-Cost WBC Indices and Procalcitonin in Rwandan Sepsis ICUs
Introduction: Sepsis in resource-limited settings Sepsis remains a leading cause of mortality worldwide, with sub-Saharan Africa facing unique challenges due to limited ICU capacity and diagnostic resources. In Rwanda, where ICU beds are scarce and advanced laboratory testing is not universally accessible, practical biomarkers are essential for early risk stratification and targeted therapy. This prospective…
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Prognostic Value of Low-Cost WBC Indices and Procalcitonin for Mortality in Rwandan Sepsis Patients: A Prospective ICU Study
Overview: Sepsis, biomarkers, and context in Rwanda Sepsis remains a leading cause of death globally, with resource-limited settings bearing a disproportionate burden. In Rwanda, where ICU capacity is constrained, identifying simple, affordable prognostic tools is critical. This study examines whether low-cost white blood cell (WBC) indices and procalcitonin (PCT) levels can predict mortality among adults…
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Glioblastoma Erodes Skull and Alters Immune Marrow
A deadly brain cancer that may not stay local Glioblastoma, the most aggressive form of brain cancer, is revealing a new and troubling dimension: it appears to interact with the body’s immune system in ways that go beyond the brain itself. In a study published in Nature Neuroscience, scientists from the Montefiore Einstein Comprehensive Cancer…
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Glioblastoma Study Reveals Skull Erosion and Immune Shifts
Groundbreaking finding: glioblastoma interacts with the skull and immune marrow Scientists from Montefiore Einstein Comprehensive Cancer Center (MECCC) and the Albert Einstein College of Medicine have shown, for the first time, that glioblastoma—one of the deadliest brain cancers—does more than invade brain tissue. The disease also erodes the skull, alters the makeup of skull marrow,…