Tag: neuroinflammation
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Australian Study Reveals Multisystem Abnormalities in ME/CFS Patients
Groundbreaking Multisystem Findings in ME/CFS In a landmark effort to understand myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), researchers in Australia have identified simultaneous abnormalities across several biological systems in people living with the condition. The study, conducted with a multimodal approach and published in a peer‑reviewed journal, strengthens the view that ME/CFS is a complex, multi-systemic…
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Lighthouse Pharmaceuticals to Present Phase 2 SPRING Trial of LHP588 at CTAD 2025
Overview of the SPRING Trial and LHP588 Lighthouse Pharmaceuticals, a Novato, California-based clinical-stage biopharmaceutical company, is poised to share new data from its Phase 2 SPRING trial of LHP588, a next-generation gingipain inhibitor designed to address P. gingivalis-positive Alzheimer’s disease. Gingipains are enzymes produced by the oral bacterium Porphyromonas gingivalis, which researchers have linked to…
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Astrocyte-Driven Approach Shows Promise in Reversing Cognitive Decline in Alzheimer’s
New Insights into Alzheimer’s: Astrocytes as Key Players In a compelling advance from Baylor College of Medicine, researchers have identified an astrocyte-driven mechanism that not only clears existing amyloid plaques in mouse models of Alzheimer’s disease but also preserves cognitive function. The study highlights a natural, brain-intrinsic process that can potentially counteract one of the…
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Inflammatory Biomarkers and the Path to Precision Medicine in Ischemic Stroke
Understanding the Dual Role of Inflammation in Ischemic Stroke Ischemic stroke occurs when a blood clot blocks a vessel, cutting off blood flow to parts of the brain. The resulting cascade includes an inflammatory response that can both harm and help recovery. On one hand, excessive inflammation can exacerbate neuronal injury, disrupt the blood-brain barrier,…
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Inflammatory biomarkers and precision medicine in ischemic stroke: paving the way for targeted care
Understanding the role of inflammation in ischemic stroke Ischemic stroke occurs when a blood clot blocks an artery, depriving brain tissue of oxygen and nutrients. The ensuing cascade triggers inflammation, a double-edged sword in stroke biology. On one hand, inflammatory responses help clear debris and promote repair. On the other, excessive or misdirected inflammation can…
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Inflammasome Proteins Offer New Path in Pediatric Traumatic Brain Injury Assessment
Breakthrough in Pediatric TBI Evaluation: Biomarkers ASC and caspase-1 A new study published in Nature Pediatric Research highlights a promising biomarker-based approach to assessing pediatric traumatic brain injury (TBI). Led by Dr. Jennifer Muñoz Pareja, the research examines serum inflammasome proteins ASC and caspase-1, revealing that their levels rise significantly in children with TBI and…
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Study Identifies New Approach to Protect the Brain During Radiation Therapy
Overview: A New Strategy to Shield the Brain During Radiation Cancer survivors often face cognitive challenges after treatment. In brain cancer, cranial radiation therapy is a standard lifesaving intervention, but it can cause lasting problems with memory, attention, and executive function. A recent experimental study from the University of California, Irvine, led by Munjal Acharya,…
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New approach protects the brain from radiation-induced cognitive decline
New research offers a targeted safeguard for brain cancer patients undergoing radiation therapy For many cancer survivors, the battle isn’t over once tumors are treated. Cognitive challenges—trouble with memory, attention, and concentration—can persist after cranial radiation therapy. In brain cancer patients, up to 70% report some form of cognitive impairment, a burden that affects independence…
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Against All Odds: The Seattle Man Defying Early-Onset Alzheimer’s Fate
Against All Odds: A Man Defies a Genetic Fate Doug Whitney, a 76-year-old retiree from Seattle, carries a rare genetic mutation that has historically forecast severe, early-onset Alzheimer’s disease. Yet, decades after the predicted onset, Whitney remains cognitively healthy. His story—shared with scientists and researchers who call him a “scientific unicorn”—is reshaping conversations about genetic…
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Investigating cannabidiol’s role in combating Alzheimer’s-related neuroinflammation
Background: the inflammation link in Alzheimer’s disease Alzheimer’s disease is commonly discussed in terms of plaques and tangles, but neuroinflammation is increasingly recognized as a driving force in its progression. Chronic immune activation within the brain can damage neurons and contribute to cognitive decline. Cannabidiol (CBD), a non-psychoactive component of cannabis, has demonstrated anti-inflammatory properties…