Tag: Neurodegeneration
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Breakthrough Study Suggests Alzheimer’s Reversal via Restored Brain Energy
Breakthrough Study Points to a Reversible Aspect of Alzheimer’s Disease For decades, Alzheimer’s disease has been considered an irreversible neurodegenerative condition. A new line of research, however, is challenging that long-held view by demonstrating that restoring energy metabolism in the brain can revive memory and cognitive function in animal models. While these findings are preliminary…
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Early Alzheimer’s Detection from Short Speech Samples Using Lightweight, Interpretable Linguistic Markers
Overview Early detection of Alzheimer’s disease (AD) remains a critical goal for enabling timely interventions, planning, and care. Recent research explores how short, naturalistic speech samples can reveal subtle linguistic and cognitive changes that precede formal diagnosis. By combining lightweight linguistic markers with interpretable models, researchers aim to create practical screening tools that clinicians, caregivers,…
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YJBM Calls for Manuscripts: Mitochondria in Health and Disease Issue
Overview The Yale Journal of Biology and Medicine (YJBM) is announcing a dedicated issue focused on mitochondria in health and disease. This special edition invites researchers from across biology, medicine, and allied fields to contribute original research articles, comprehensive reviews, and perspective pieces exploring how mitochondrial function and dysfunction influence health, aging, metabolism, neurodegeneration, cancer,…
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Lighthouse Pharmaceuticals to Present Phase 2 SPRING Trial of LHP588 for P. gingivalis–Positive Alzheimer’s at CTAD 2025
Overview: A Targeted Approach to a Complex Neurodegenerative Challenge In a bid to address an emerging and controversial hypothesis in Alzheimer’s disease (AD) research, Lighthouse Pharmaceuticals announced the Phase 2 SPRING trial results for LHP588, a next-generation gingipain inhibitor, at the Clinical Trials on Alzheimer’s Disease (CTAD) 2025 conference. The company positions LHP588 as a…
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Untreated Sleep Apnea Doubles Parkinson’s Risk
Overview: The Link Between Sleep Health and Neurodegenerative Risk Recent research analyzing more than 11 million medical records has found a significant association between untreated obstructive sleep apnea (OSA) and an increased risk of developing Parkinson’s disease over time. While sleep disorders have long been known to affect quality of life and daytime functioning, this…
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Untreated Sleep Apnea Doubles Parkinson’s Risk: What the New Study Reveals
What the study found A new, large-scale analysis using more than 11 million medical records has found a concerning link between untreated obstructive sleep apnea (OSA) and an increased risk of developing Parkinson’s disease (PD) later in life. The study, which followed diverse populations over several years, indicates that individuals with untreated OSA faced a…
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Astrocyte-Driven Reversal of Alzheimer’s Cognitive Decline: Mouse Study Sparks Hope
Groundbreaking Astrocyte Findings Point to a Natural Brain Cleanup Mechanism A recent study from Baylor College of Medicine highlights a promising, naturally occurring brain process that helps clear amyloid plaques and maintain cognitive function in mouse models of Alzheimer’s disease. The research focuses on astrocytes, star-shaped support cells in the brain, and how they can…
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Astrocyte-Driven Therapy Shows Promise for Reversing Cognitive Decline in Alzheimer’s
New Astrocyte-Driven Mechanism Clears Amyloid Plaques and Preserves Cognition Scientists at Baylor College of Medicine have identified a natural, brain-immune process that can clear amyloid plaques and protect cognitive function in mouse models of Alzheimer’s disease. By harnessing the activity of astrocytes, a type of glial cell that supports and modulates neurons, researchers demonstrated a…
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Polymer Physics Sheds Light on Tau Fibril Formation in Alzheimer’s
New Cross-Disciplinary Insight into Alzheimer’s Pathology Researchers at Tokyo Metropolitan University have bridged fields by applying concepts from polymer physics to the study of tau protein fibrillogenesis, a central feature of Alzheimer’s disease pathology. By treating tau proteins as dynamic polymers that can assemble, rearrange, and crystallize under cellular conditions, the team is uncovering the…
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The Brain’s Hidden Drain: A New Look at Waste Clearance
What is the brain’s hidden drain? The brain, long thought to be protected from waste buildup by the blood-brain barrier, has a sophisticated waste clearance network that researchers are only beginning to map in detail. A recently described system points to a network of lymphatic vessels in the membranes surrounding the brain, working in concert…