Tag: neocortex
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Modeling and Simulation of Neocortical Micro- and Mesocircuitry (Part I, Anatomy)
Introduction: The Quest to Model the Neocortex Understanding how the neocortex computes begins with its anatomy. Modern modeling and simulation efforts aim to bridge the gap between microscopic cellular properties and macroscopic cognitive functions. Part I focuses on anatomy—the layered structure, diverse cell types, and synaptic connectivity that constitute the cortical micro- and mesocircuitry. A…
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Modeling and Simulation of Neocortical Micro- and Mesocircuitry: Anatomy (Part I)
Introduction to Neocortical Architecture The neocortex, a hallmark of mammalian cognition, is organized into repeating microcircuits that also integrate into larger mesocircuits. Understanding its anatomy is the first essential step for realistic modeling and simulation. This Part I article–focusing on anatomy–lays the groundwork for data-driven, biophysically detailed models that aim to capture cortical dynamics with…
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Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy)
Introduction: Why anatomy matters in neocortical modeling Understanding the cortex begins with its anatomy. The neocortex orchestrates perception, memory, and higher cognitive functions through complex interactions across micro- and mesocircuit scales. In modern computational neuroscience, data-driven, biophysically detailed models rely on accurate anatomical descriptions to simulate realistic dynamics. This Part I (anatomy) sets the foundation…