Tag: Nature Methods
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Cryo-imaging Breakthrough Reveals Thick Biological Structures with Greater Clarity
Overview: A New Window into Thick Biological Samples Cryo-imaging has long promised a clearer view of biological materials in their near-native state. Traditional electron microscopy, while superb for isolated molecules, struggles with thicker samples. A Cornell-led team has unveiled a transformative method—tilt-corrected bright-field scanning transmission electron microscopy (tcBF-STEM)—that delivers higher contrast and dramatically increased efficiency…
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Cryo-imaging Reveals Deeper View of Thick Biological Materials
A New Window into Thick Biological Samples Cryo-imaging has taken a notable leap forward with a method called tilt-corrected bright-field scanning transmission electron microscopy (tcBF-STEM). Developed by a team at Cornell, this technique enables high-contrast imaging of thick biological materials that were previously challenging to study with electron microscopy. By rethinking how detectors capture electrons…
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Cryo-imaging Breakthrough: tcBF-STEM Delivers Deeper Views of Thick Biological Materials
Revolution in Cryo-imaging: A Deeper Look into Thick Biological Materials Imaging thick biological specimens has long posed a challenge for scientists seeking to understand how molecules operate within their cellular environments. Traditional transmission electron microscopy (TEM) can blur images when samples are too thick because energy loss and scattering degrade resolution. A team at Cornell…