Tag: Nature Immunology
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Switching Immune-Cold Tumors to Immune-Hot: A Breakthrough Path to Durable Cancer Immunity
Turning the Tide on Immune-Cold Tumors In a pivotal study published in Nature Immunology, scientists reveal a strategy that could make aggressive, immune-suppressive tumors more vulnerable to the body’s defenses. Funded by the National Cancer Institute/NIH, the research builds on prior work in breast cancer to show that transforming the tumor microenvironment can awaken a…
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Switching Immune Cold Tumors to Immune Hot: A Breakthrough in Cancer immunotherapy
Overview: Turning immune-cold tumors into immune-hot targets In a significant advance for cancer immunotherapy, researchers have identified a strategy to reprogram immune-cold tumors—those that typically evade detection—into immune-hot tumors that recruit and coordinate immune cells to attack cancer. The study, recently published in Nature Immunology, builds on decades of work to harness the body’s own…
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Researchers Discover a Switch that Transforms Immune-Cold Tumors into Immune-Hot, Boosting Cancer Therapy
Transforming Immune-Cold Tumors into Immune-Active Targets Cancer research has long grappled with tumors that evade the body’s defenses. A recent study published in Nature Immunology, backed by the National Cancer Institute/NIH, reports a promising strategy to convert these immune-cold tumors into immune-hot ones. By priming the tumor environment with immune-activating signals, researchers observed a robust,…
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Checkpoint inhibitors reveal tissue repair role, offering hope for chronic wounds
Unveiling a new function for a familiar immune brake Checkpoint inhibitors are well known for their role in cancer therapy, where they release the immune system’s brakes to attack tumor cells. In a surprising twist, researchers from the University of Zurich (UZH) have uncovered a second, equally important function: TIGIT, a checkpoint protein, promotes tissue…
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Checkpoint Inhibitor TIGIT Promotes Tissue Repair
New role for checkpoint inhibitors in tissue healing Checkpoint inhibitors are best known for unleashing the immune system against cancer. A surprising new perspective emerging from researchers at the University of Zurich (UZH) shows that one of these inhibitors, TIGIT, also plays a vital part in tissue repair. Published in Nature Immunology, the study reveals…
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Checkpoint inhibitors aid tissue repair, offering new hope for chronic wounds
Summary: A new role for checkpoint inhibitors in tissue repair Checkpoint inhibitors, best known for unleashing the immune system against cancer, may also help heal damaged tissues. Researchers at the University of Zurich (UZH) have identified a previously unknown function of one such inhibitor, TIGIT: it promotes tissue repair after viral infection. The discovery, published…