Tag: Mouse model
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Lauric Acid and Levodopa Mitigate Manganese-Induced Ovarian Toxicity in Mice Through Antioxidative, Anti-Inflammatory, and Steroidogenic Pathways
Overview Manganese, a naturally occurring element, can exert toxic effects on the female reproductive system at high exposure levels. Recent experimental work in BALB/c mice explored whether two compounds, lauric acid and levodopa, individually or together, can attenuate manganese-induced ovarian toxicity. The study centers on antioxidative, anti-inflammatory, and steroidogenic pathways as key mediators of protection.…
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Investigating cannabidiol’s role in combating Alzheimer’s-related neuroinflammation
Background: the inflammation link in Alzheimer’s disease Alzheimer’s disease is commonly discussed in terms of plaques and tangles, but neuroinflammation is increasingly recognized as a driving force in its progression. Chronic immune activation within the brain can damage neurons and contribute to cognitive decline. Cannabidiol (CBD), a non-psychoactive component of cannabis, has demonstrated anti-inflammatory properties…
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Cannabidiol Shows Promise in Reducing Alzheimer’s-Related Neuroinflammation in Mouse Model
Overview: CBD as a potential anti-inflammatory strategy for Alzheimer’s disease Neuroinflammation is increasingly recognized as a central driver of neuronal damage in Alzheimer’s disease (AD). While the classic hallmarks of AD—amyloid plaques and tau tangles—have guided much research, chronic immune activation within the brain also accelerates cognitive decline. A new study in eNeuro by Babak…
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CBD and Alzheimer’s: Combatting Neuroinflammation in Mice
Understanding the link between neuroinflammation and Alzheimer’s Neuroinflammation is increasingly recognized as a pivotal driver of neuronal damage in Alzheimer’s disease. While much attention has centered on amyloid plaques and tau tangles, chronic immune activation within the brain—often driven by microglia and other glial cells—can accelerate neurodegeneration. A growing body of work suggests that modulating…
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Telomere Length Inheritance: Why It Matters for Health
Telomeres: what they are and why they shorten Telomeres are protective caps at the ends of chromosomes, made of repetitive DNA and specialized proteins. Each time a cell divides, these caps shorten a little. When telomeres become critically short, cells stop dividing in a state called cellular senescence. This process is linked to chronic inflammation…
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MaGNet: A Mammary Gland Network for Breast Branching Analysis
MaGNet: A fast, image-based tool for mapping mammary gland branching Branching in tissues isn’t limited to trees. In female mammals, the mammary gland undergoes extensive branching after birth, during puberty and again in pregnancy as milk ducts grow and reorganize. Understanding this architecture is crucial because disturbances in branching have been linked to breast cancer…
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MaGNet: Automated Mammary Gland Branch Analysis Tool
What MaGNet Is Branching is a fundamental biological pattern, shaping how organs grow and function. In the female mammary gland, ducts branch extensively during puberty and again in pregnancy to prepare for lactation. Disturbances in this architecture can be linked to cancer risk, but studying the intricate branching has long been a slow, manual endeavor.…
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AI-Optogenetics Platform for Early Parkinson’s Diagnosis and Therapy
A Groundbreaking Platform: AI Meets Optogenetics KAIST researchers have unveiled a pioneering preclinical platform that fuses artificial intelligence (AI) with optogenetics to advance both the diagnosis and treatment of Parkinson’s disease. The announcement, made by KAIST president Kwang Hyung Lee on September 22, highlights a collaboration spanning the university’s Biological Sciences, Brain and Cognitive Sciences,…