Tag: molecular epidemiology
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CRE Acquisition After Colistin Monotherapy vs Colistin-Meropenem: Insights from the AIDA Trial
Overview Carbapenem-resistant Enterobacterales (CRE) infections pose a major challenge across healthcare settings due to limited treatment options and high mortality. The AIDA randomized trial investigates how initial treatment choices—specifically colistin monotherapy versus a combination of colistin with meropenem—may influence subsequent acquisition and molecular characteristics of CRE isolates. This article summarizes the study’s aims, methods, key…
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Pioneering personalized medicine: deciphering depression’s complex biology
Pioneering a systemic view of depression through multi-omics Depression has long been treated as a primarily brain-centric disorder, its causes sought in neurotransmitter imbalances and regional brain activity. A ground‑breaking Genomic Press interview with Dr. Najaf Amin, Oxford University Associate Professor and a leader in molecular epidemiology, shifts that narrative. Her team’s work spans genomics,…
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Long-Term Molecular Surveillance of Cryptosporidium and Giardia in Wildlife Across Melbourne’s Protected Drinking Water Catchments
Overview of a Decade-Plus Surveillance Program Ensuring safe drinking water from natural catchments requires detailed knowledge of protozoan parasites in wildlife. This long-term study tracks Cryptosporidium and Giardia in Melbourne’s protected catchments using cost-effective molecular methods to identify and classify parasites in host wildlife. Spanning 2009–2024 with updates through 2024, the program provides a comprehensive…
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Long-Term molecular surveillance of Cryptosporidium and Giardia in wildlife in protected drinking water catchments
Overview of a long-term molecular survey in protected catchments Maintaining safe drinking water from natural catchments requires understanding protozoan pathogens in wildlife. This longitudinal study analyzes Cryptosporidium and Giardia from 8,695 fecal DNA samples collected across 16 years (2009–2024) in Melbourne, Australia’s protected catchments. Using PCR-based sequencing and phylogenetic analyses, researchers identified 12 Cryptosporidium species/genotypes…