Tag: metastasis
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Mapping metastasis: how nutrient availability shapes breast cancer’s spread
Understanding how breast cancer metastasizes Breast cancer remains a leading cause of cancer-related mortality, in part because malignant cells can migrate from the primary tumor to distant organs. A growing body of research shows that where cancer cells settle is not random. The nutrient landscape of each organ—its available sugars, amino acids, lipids, and other…
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Metastasis mapping: nutrient availability in breast cancer
Understanding how nutrients steer breast cancer spread Breast cancer does not spread uniformly. While tumor cells can invade many tissues, their ability to colonize different organs depends on a complex set of factors. Recent work summarized under the title “Nutrient requirements of organ-specific metastasis in breast cancer” highlights a growing understanding: the microenvironment’s nutrient landscape…
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Mapping Metastasis: How Nutrient Availability Shapes Breast Cancer’s Spread
Understanding the Role of Nutrients in Breast Cancer Metastasis Breast cancer can spread (metastasize) to multiple organs, yet the reasons behind why certain sites become preferred targets remain unclear. A growing body of research is revealing that the nutrient landscape of distant organs—what nutrients are plentiful, and how tumors tap into them—plays a pivotal role…
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Pancreatic Cancer Research Project Targets Seeds of Metastasis
New Frontiers in Pancreatic Cancer Research Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest forms of cancer, with a five-year survival rate that has stubbornly lingered in the single digits. A recent research initiative is focusing on a critical phase of disease progression: the early steps that allow pancreatic cancer cells to seed distant…
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Pancreatic Cancer Research Targets Seeds of Metastasis
New frontiers in the fight against pancreatic cancer Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal forms of cancer, often diagnosed at late stages when treatment options are limited. A leading reason for its grim prognosis is the way PDAC quickly seeds metastasis, spreading to the liver, lungs, and other organs. In a…
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EZH2 Inhibition Blocks TNBC Metastasis and Restores Chromosomal Stability
New findings link EZH2 to chromosomal chaos and metastasis in TNBC Triple-negative breast cancer (TNBC) remains one of the most challenging cancer types to treat due to its aggressive nature and lack of targeted hormones. A groundbreaking preclinical study from Weill Cornell Medicine, published in Cancer Discovery, identifies a surprising driver of TNBC metastasis and…
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Blocking TNBC Metastasis by Restoring Chromosomal Stability via EZH2 Inhibition
New findings link EZH2 to TNBC metastasis and chromosomal instability Triple negative breast cancer (TNBC) remains one of the most challenging cancer types to treat, largely due to its propensity to spread to distant organs. A new preclinical study led by Weill Cornell Medicine uncovers a surprising mechanism: an enzyme called EZH2 drives abnormal cell…
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New Strategy Targets EZH2 to Block TNBC Metastasis and Restore Chromosomal Stability
Breakthrough in Triple-Negative Breast Cancer: Targeting EZH2 to Halt Metastasis Triple-negative breast cancer (TNBC) remains one of the most aggressive and hard-to-treat forms of breast cancer. A new preclinical study from Weill Cornell Medicine proposes a surprising and hopeful strategy: inhibiting an enzyme called EZH2 to prevent cancer cells from disseminating to distant organs by…
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NAMs Reveal Cancer Cells’ Hidden Power Source Under Stress
Scientists unveil a hidden power source inside cancer cells In a breakthrough that could reshape how we understand cancer survival, researchers from the Centre for Genomic Regulation (CRG) in Barcelona have identified a rapid mitochondrial response inside squeezed cancer cells. When cancer cells endure the brutal mechanical gauntlets of moving through a tumor’s dense matrix…
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Cancer Cells’ Hidden Power Source: NAMs Boost DNA Repair Under Mechanical Stress
Unveiling a Hidden Power Source in Cancer Cells A groundbreaking study from the Centre for Genomic Regulation (CRG) in Barcelona reveals that cancer cells possess a rapid, localized energy boost when they are squeezed through tight spaces. In experiments using a specialized microscope that compresses living cells to three microns wide, researchers observed a dramatic,…