Tag: MAPK
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Interplay of lncRNAs and MAPK Signaling in Breast Cancer Pathogenesis
Overview: lncRNAs and the MAPK Signaling Web in Breast Cancer Breast cancer pathogenesis is shaped by intricate signaling networks, with MAPK pathways acting as central hubs that govern proliferation, survival, migration, and angiogenesis. Long non-coding RNAs (lncRNAs) have emerged as influential regulators of these cascades, operating as molecular sponges, scaffolds, and downstream effectors. This article…
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LncRNA-MAPK Interplay in Breast Cancer: Unlocking New Paths for Therapy
Introduction: Why lncRNAs and MAPK Matter in Breast Cancer Breast cancer is driven by a network of signaling pathways that control cell growth, survival, and metastasis. Among these, the mitogen-activated protein kinase (MAPK) cascades—comprising ERK, JNK, and p38—translate extracellular cues into precise cellular responses. In recent years, long non-coding RNAs (lncRNAs) have emerged as powerful…
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LncRNAs and MAPK Signaling in Breast Cancer: Interplay Driving Pathogenesis and Therapy Options
Introduction: The MAPK Landscape in Breast Cancer MAPK signaling is a cornerstone of cellular decision-making, translating external cues into outcomes such as proliferation, differentiation, migration, and survival. In breast cancer, three major MAPK branches—ERK, JNK, and p38—coordinate responses to growth factors, cytokines, and stress signals. While mutations in upstream components frequently hijack this network, noncoding…