Tag: kiss-shrink-run


  • Cryo-ET Uncovers Kiss-Shrink-Run: A Hybrid Mechanism for Synaptic Vesicle Exocytosis

    Cryo-ET Uncovers Kiss-Shrink-Run: A Hybrid Mechanism for Synaptic Vesicle Exocytosis

    Breaking the old dichotomy in neurotransmission For decades, neuroscientists debated whether synaptic vesicles released neurotransmitters through a fleeting “kiss-and-run” event or an irreversible “full collapse” into the presynaptic membrane. A pioneering study from the University of Science and Technology of China (USTC) now reveals a nuanced third act—one that reconciles two long-standing models by showing…

  • Cryo-ET Unveils Kiss-Shrink-Run: A Hybrid Model of Neurotransmitter Release

    Cryo-ET Unveils Kiss-Shrink-Run: A Hybrid Model of Neurotransmitter Release

    Cracking the Code of Neurotransmission The brain’s ability to transmit signals rapidly hinges on the precise choreography of synaptic vesicle exocytosis. For decades, scientists debated whether vesicles simply “kiss” the presynaptic membrane and retreat (kiss-and-run) or fully collapse to release their neurotransmitters. A groundbreaking study from the University of Science and Technology of China (USTC),…