Understanding the question: What is artemisinin resistance? Artemisinin-based combination therapies (ACTs) are the frontline treatment for uncomplicated malaria caused by Plasmodium falciparum. In parts of Asia, resistance to artemisinin arose when the parasite evolved mutations in the kelch13 (K13) gene, slowing parasite clearance after drug exposure. Over time, resistance also spread to partner drugs, complicating…