Tag: JAMA Cardiology
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Non-DNMT3A CHIP Variants Linked to Higher Heart Failure Risk in Older Adults
Overview: CHIP and its Subtypes Clonal hematopoiesis of indeterminate potential (CHIP) is a condition in which blood-forming stem cells acquire somatic mutations and expand clonally. With age, CHIP becomes more common, and it has been associated with a range of cardiovascular and hematologic outcomes. While DNMT3A is among the most frequently mutated CHIP genes, a…
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Non-DNMT3A CHIP Variants Elevate Heart Failure Risk in Older Adults
What is CHIP and why it matters? Clonal hematopoiesis of indeterminate potential (CHIP) describes a mosaic of blood cells that carry somatic mutations, typically acquired with age. While many CHIP mutations are harmless in themselves, certain gene variants are increasingly associated with adverse cardiovascular outcomes. A growing body of research highlights how CHIP can influence…