Tag: interferon signaling
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Understanding Immunotherapy Resistance in Kidney Cancer: The Role of Myeloid Cell Signaling
Overview: A New Mechanism Driving Immunotherapy Resistance in Kidney Cancer Immunotherapy has transformed the treatment landscape for advanced renal cell carcinoma (RCC), offering durable responses for some patients. Yet a significant proportion of individuals experience resistance, limiting the long-term effectiveness of immune-based therapies. A landmark study published in Immunity in October 2025 identifies a key…
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Unraveling Immunotherapy Resistance in Kidney Cancer: The Role of Myeloid Cell Signaling
Overview: Immunotherapy and the Challenge in Advanced Kidney Cancer Immunotherapy has transformed treatment for many cancers, including renal cell carcinoma (RCC). Yet a significant subset of patients with advanced RCC experience limited benefit due to intrinsic or acquired resistance. A recent research focus centers on the tumor microenvironment, where immune and myeloid cells communicate in…
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Myeloid-Driven Immunotherapy Resistance in Kidney Cancer: Interferon Signaling Under Scrutiny
Overview: A New Mechanism Behind Immunotherapy Resistance in Kidney Cancer Immunotherapy has transformed the treatment landscape for advanced renal cell carcinoma (RCC), but responses remain inconsistent. A landmark study published in Immunity (October 2025) by researchers including Dana-Farber Cancer Institute’s Eliezer M. Van Allen, MD, identifies a critical role for myeloid cells in shaping resistance…