Tag: Immunology
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Hypoxia Reprograms Neutrophils: Long-Term Immune Impact
Hypoxia and the immune system: a surprising link Scientists are uncovering how low oxygen levels, or hypoxia, can do more than cause immediate trouble breathing. New research suggests that hypoxia can reprogram a key group of immune cells—neutrophils—by changing the way their genetic material is packaged. This finding points to a lasting impact on the…
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HIV Research: A Catalyst for Breakthroughs Across Medicine
The Enduring Impact of HIV Research HIV/AIDS research has become more than a focused effort against a single disease. Over the past four decades, U.S.-funded HIV research has advanced science in ways that touch immunology, cancer therapy, vaccines, and global health at large. A recent Nature Medicine commentary by leading researchers highlights how this sustained…
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HIV Research: A Catalyst for Global Medicine and Innovation
Introduction: A Forty-Year Arc of Impact HIV/AIDS research has not only transformed care for people living with HIV but has become a powerful engine of scientific discovery across medicine. In a recent Nature Medicine commentary, leading researchers reflect on four decades of U.S.-funded HIV science and its outsized influence on immunology, cancer therapy, cardiovascular and…
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How HIV/AIDS Research Transformed Global Health: From Immunology to Cancer Therapies and Beyond
HIV Research as a Catalyst for Broad Scientific Advances Four decades of U.S.-funded HIV/AIDS research have done more than extend lives affected by the virus. In a recent Nature Medicine commentary, scientists emphasize that the pursuit of HIV prevention, treatment, and cure has become a powerful engine for understanding human biology and developing therapies for…
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Portlaoise Boy Finds Life-Changing Cure Through Groundbreaking ADA-SCID Gene Therapy
Groundbreaking Gene Therapy Brings New Hope for ADA-SCID Patients A nine-year-old boy from Portlaoise, Ireland, has become one of the most compelling success stories in recent medical research after participating in a landmark gene therapy trial. Andy Cash, diagnosed with adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID) as a newborn, has seen transformative improvements that his…
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Checkpoint inhibitors reveal tissue repair role, offering hope for chronic wounds
Unveiling a new function for a familiar immune brake Checkpoint inhibitors are well known for their role in cancer therapy, where they release the immune system’s brakes to attack tumor cells. In a surprising twist, researchers from the University of Zurich (UZH) have uncovered a second, equally important function: TIGIT, a checkpoint protein, promotes tissue…
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Checkpoint Inhibitor TIGIT Promotes Tissue Repair
New role for checkpoint inhibitors in tissue healing Checkpoint inhibitors are best known for unleashing the immune system against cancer. A surprising new perspective emerging from researchers at the University of Zurich (UZH) shows that one of these inhibitors, TIGIT, also plays a vital part in tissue repair. Published in Nature Immunology, the study reveals…
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TIGIT: Immune Checkpoint Promoter of Tissue Healing Could Change Fibrosis and Wound Care
Groundbreaking finding: TIGIT helps tissue repair Researchers at the University of Zurich (UZH) have uncovered a surprising role for the immune checkpoint inhibitor TIGIT beyond its well-known function as a cancer therapy target. In a study led by Nicole Joller, the team demonstrated that TIGIT not only helps regulate immune responses during infections but also…
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TIGIT Promotes Tissue Healing: A New Role for Immune Checkpoints
Unlocking a Hidden Role for Immune Checkpoints Immune checkpoint inhibitors are best known as cancer therapies that unleash the body’s defenses against tumors. A team from the University of Zurich (UZH) has uncovered a surprising new function for one of these molecules: TIGIT, a surface receptor on immune cells, also promotes tissue healing after viral…
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TIGIT Immune Checkpoint Promotes Tissue Healing and Regeneration
Overview: A new role for an immune checkpoint Immune checkpoint inhibitors have transformed cancer therapy by releasing the brakes on the immune system. A surprising new finding from researchers at the University of Zurich (UZH) reveals that one such brake, TIGIT, does more than help tumor-fighting immune cells—it also promotes tissue healing. This discovery could…