Tag: hydrogenase
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Gut hydrogenase: the hidden engine behind gut hydrogen production and Crohn’s disease
Introduction: A new look at the gut’s hydrogen economy In the complex world inside our intestines, microscopic microbes carry out countless reactions that influence health. Among these, the production and management of molecular hydrogen (H₂) have long been an underappreciated piece of the puzzle. A recent multinational study published in Nature Microbiology pinpoints the primary…
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Gut’s Hidden Hydrogen Engine: How a Key Enzyme Fuels Healthy Guts and Falters in Crohn’s Disease
Unveiling the gut’s hydrogen engine Scientists have long known that the human gut is a bustling metabolic reactor. Carbohydrates are fermented by trillions of microbes, yielding energy, beneficial short-chain fatty acids, and a spectrum of gases. Among these gases, molecular hydrogen (H₂) plays a surprising and crucial role. Rather than being a mere byproduct, H₂…
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A Hidden Hydrogen Engine in the Gut: How It Falters in Crohn’s Disease
Overview: A breakthrough in gut hydrogen metabolism Scientists have uncovered a key driver of hydrogen production in the healthy human gut and shown how its decline reshapes microbial energy networks in Crohn’s disease (CD). Published in Nature Microbiology, the study combines genomics, transcriptomics, and biochemistry to map the enzymes responsible for fermentative hydrogen (H₂) production…