Tag: host-directed therapy
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Pin1 Inhibitors Could Stop Cold Sores by Reshaping Cellular Barriers
New antiviral strategy targets host cell structures to combat HSV-1 Researchers are exploring a novel class of antivirals that go beyond directly attacking viruses. Pin1 inhibitors, a group of compounds that modulate the host enzyme peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1), have shown promise in curbing herpes simplex virus 1 (HSV-1) replication. HSV-1 is the…
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Pin1 Inhibitors Could Halt HSV-1 Outbreaks In Humans
New Pin1 Inhibitors Offer a New Way to Combat Cold Sores Researchers are exploring a novel class of antivirals that could change how we prevent and treat oral herpes. Pin1 inhibitors, designed to target a cellular enzyme called peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1), have shown potential to curb herpes simplex virus 1 (HSV-1) replication.…
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Targeted Steroid Use Could Complement TB Treatment by Boosting Macrophage Defense
Overview: Rethinking Steroids in TB care Tuberculosis (TB) remains a global health challenge, infecting more than 10 million people annually and claiming around 1.25 million lives each year. While corticosteroids like dexamethasone are used in select TB scenarios, notably TB meningitis, their broader impact on immune cells—especially lung macrophages—has been unclear. A new study from…
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Targeted steroid use may boost macrophage defenses to fight TB
New insights into how dexamethasone could aid TB treatment Tuberculosis (TB) remains a global health challenge, affecting more than 10 million people annually and causing around 1.25 million deaths each year. Amid ongoing efforts to curb TB, researchers at Trinity College Dublin, based at St James’s Hospital in Dublin, are revisiting the role of steroids…
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Targeted steroid use may offer a universal complementary treatment to fight TB
Overview: A new angle on TB treatment Tuberculosis (TB) continues to be a major global health challenge, affecting more than 10 million people annually with about 1.25 million deaths each year. While steroids such as dexamethasone are already used in selected TB cases, the precise impact of these drugs on immune cells has remained unclear.…
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Disabling a Cellular ‘Entry Code’ Could Stop Deadly Rotavirus Infection
New Target in the War Against Rotavirus Rotavirus remains a leading cause of severe dehydrating diarrhea in infants and young children, claiming more than 128,500 lives globally each year despite broad vaccination efforts. In the United States, a worrying trend toward waning vaccine uptake has coincided with rising rotavirus cases in recent years. A team…