Tag: HNSCC
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BATF2: Glutamine-Driven Silencing of a Novel Tumor Suppressor in Head and Neck Cancer
Introduction A groundbreaking study from researchers at The University of Texas MD Anderson Cancer Center reveals that BATF2, a newly identified tumor suppressor gene, is silenced by metabolic factors in the tumor microenvironment. Specifically, glutamine appears to suppress BATF2 activity, dampening the immune response against head and neck cancer in five preclinical models. This discovery…
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BATF2: A Glutamine-Driven Silencing of a Tumor Suppressor in Head and Neck Cancer
Overview: BATF2 as a Tumor Suppressor in Head and Neck Cancer BATF2 is emerging as a critical tumor suppressor whose activity helps mobilize the immune system against head and neck cancers. In preclinical studies led by researchers at The University of Texas MD Anderson Cancer Center, BATF2 function was consistently reduced in several models of…
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Treating Head and Neck Squamous Cell Carcinoma with Intratumoral Bacteria: New Hope from Radiation and Chemotherapy Advances
Understanding the Breakthrough Head and neck squamous cell carcinoma (HNSCC) is a challenging cancer type, often requiring aggressive radiation and chemotherapy regimens. Recent research, including an international multicenter trial led by MSK radiation oncologist Dr. Nancy Lee, has explored a provocative idea: bacteria residing inside tumors can impact how cancer responds to standard treatments. This…
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Intratumoral Bacteria and the Future of Head and Neck Squamous Cell Carcinoma Treatment: Insights from a Pioneering Trial
Understanding the Role of Intratumoral Bacteria in Head and Neck Squamous Cell Carcinoma Head and neck squamous cell carcinoma (HNSCC) remains a challenging cancer to treat, with outcomes closely tied to tumor biology and the surrounding microenvironment. A growing area of research focuses on the microbiome that resides within tumors — the intratumoral bacteria. Recent…