Tag: HIF-1α
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Decoding Sepsis Signaling and Metabolic Dysregulation
Introduction: The Signaling Web Behind Sepsis Sepsis is a life-threatening syndrome driven by dysregulated immune responses and widespread metabolic disruption. Modern research reveals that sepsis emerges from an intricate network of signaling pathways that control inflammation and cellular energy. By decoding these networks—rather than focusing on a single target—we can better understand disease progression and…
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Decoding Signaling Networks and Metabolic Dysregulation in Sepsis: Toward Dynamic, Multi-Target Therapies
Introduction: Sepsis as a Signaling and Metabolic Challenge Sepsis is a complex, life-threatening syndrome driven by dysregulated immune responses, systemic inflammation, and widespread metabolic disruption. Traditional treatments, centered on antibiotics and early goal-directed therapy, often fall short due to the dynamic and heterogeneous nature of the disease. A growing body of research points to a…
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Decoding Signaling Networks and Metabolic Dysregulation in Sepsis
Understanding Sepsis: A Web of Signaling and Metabolism Sepsis is a life-threatening syndrome arising from infection that triggers a dysregulated immune response and widespread organ dysfunction. Modern research paints a picture of sepsis not as a single pathway anomaly but as a complex network of interlocking signaling cascades and metabolic changes. Central to this network…