Tag: GPX4
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Dual Role of SLC7A11 in Colorectal Cancer Ferroptosis: A Molecular Balancing Act
Overview: Ferroptosis in Colorectal Cancer Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. In recent years, ferroptosis—a regulated form of cell death driven by iron-dependent lipid peroxidation—has emerged as a promising target for cancer therapy. Central to the ferroptosis axis is SLC7A11, a key component of system xc− that imports cystine in…
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The Dual Role of SLC7A11 in Colorectal Cancer Ferroptosis: From Molecules to Therapies
Understanding Ferroptosis and SLC7A11 Ferroptosis is a regulated form of cell death driven by iron-dependent lipid peroxidation. In colorectal cancer (CRC), ferroptosis represents a promising avenue to overcome resistance to conventional therapies. Central to this process is SLC7A11, a component of the cystine/glutamate antiporter system Xc–, which imports cystine into cells in exchange for glutamate.…
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The Dual Role of SLC7A11 in Colorectal Cancer Ferroptosis: A Molecular Tug-of-War
Understanding Ferroptosis and SLC7A11 in Colorectal Cancer Colorectal cancer (CRC) remains a major global health challenge, driven by complex metabolic and genetic alterations. A relatively new area of cancer biology—ferroptosis—refers to an iron-dependent form of regulated cell death triggered by lipid peroxidation. At the center of this process lies SLC7A11, a cystine/glutamate antiporter, which plays…