Tag: Genomics
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Depression Brain Cells Identified: Key Neurons and Microglia
Groundbreaking study pinpoints brain-cell targets in depression In a landmark effort to understand the biology of depression, researchers have for the first time pinpointed the exact brain cell types where gene activity and DNA regulation are disrupted. The team combined advanced genomic techniques with post-mortem brain tissue to identify the cells most affected by depression,…
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Depression Revealed: Specific Brain Cells Linked to the Condition Identified by Researchers
New Breakthrough Maps Which Brain Cells Carry Depression For the first time, scientists have pinpointed the exact brain cell types that change in depression by combining gene activity maps with DNA regulatory mechanisms. The discovery comes from analyzing post-mortem brain tissue with cutting-edge, single-cell genomic methods, shedding new light on the biological roots of a…
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For the first time, scientists pinpoint brain cells linked to depression
Groundbreaking discovery maps which brain cells are affected in depression In a landmark study, researchers have for the first time pinpointed the specific brain cell types that show altered activity in depression. By combining gene activity data with mechanisms that regulate the DNA code, the team has created a clearer map of where disruptions occur…
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Pan-Cancer AI Model Elevates Prognosis Across 30 Cancer Types with MICE
Transforming Pan-Cancer Prognosis with Multimodal AI In the rapidly evolving field of oncology, a novel multimodal AI model named MICE (Multimodal data Integration via Collaborative Experts) is breaking new ground in pan-cancer prognosis prediction. By integrating pathology images, genomics, and clinical data, MICE demonstrates superior generalizability and efficiency across 30 cancer types. The approach aims…
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Comparative Chloroplast Genomics of Erigeron (Asteroideae, Asteraceae): Insights from a Broad Phylogenomic Survey
Overview: Why Compare Erigeron Chloroplast Genomes? Erigeron, commonly known as fleabanes, includes hundreds of species spread across temperate and mountainous regions worldwide. Unraveling their evolutionary relationships is challenging due to polyphyly, hybridization, and taxonomic ambiguity, especially among Old World taxa. A comprehensive comparative study of chloroplast (cp) genomes provides a stable, maternally inherited genetic framework…
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Genomic study reveals epigenetic drivers in osteosarcoma guiding tailored therapies
New genomic insights illuminate osteosarcoma biology Osteosarcoma, the most common bone cancer in children and adolescents, has long challenged clinicians with its aggressive course and tendency toward chemotherapy resistance. A new study led by Livia Garzia, PhD, Nada Jabado, MD, PhD, and Claudia Kleinman, PhD, from The Research Institute of the McGill University Health Centre…
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Genomic Insights Offer Hope for Tailored Osteosarcoma Therapies
New genomic study highlights epigenetic drivers of osteosarcoma An international team led by Livia Garzia, PhD, Nada Jabado, MD, PhD, and Claudia Kleinman, PhD, has unveiled important epigenetic features in osteosarcoma, offering fresh directions for prognosis and treatment. The findings, published in Nature Communications, illuminate how epigenetic regulation shapes this aggressive bone cancer that primarily…
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Mitochondrial Genome of Plasmodium pitheci in Bornean Orang-utans Reveals Close Relations Within Orang-utan Malaria Lineages
Background: Orang-utan malaria and the Plasmodium pitheci discovery Malaria in non-human primates (NHP) spans a diverse genus, with Plasmodium species infecting a broad host range. Among Asian NHPs, orang-utans (Pongo spp.) harbor Plasmodium pitheci and Plasmodium sylvaticum, parasites historically identified by morphology but lacking validated molecular characterization until now. The present work focuses on the…
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How Bats Reused Old Genes to Take Flight: The Evolution of the Wing
Introduction: The Mystery Behind a Flying Mammal Bats are the only mammals capable of true powered flight. Their wings differ dramatically from the typical mammalian limb, yet they sprouted from the same five-digit limb pattern found in mice, humans, and dolphins. How did evolution turn a familiar blueprint into a remarkable flying apparatus? Early expectations…
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Explainable AI in Cancer Detection: Dr. Sakib Mostafa’s Path from Fear to Innovation
Unpacking the Black Box: Why Explainable AI Matters Artificial intelligence is reshaping healthcare, but its most consequential risks aren’t tubes of metal marching toward dystopian futures. They’re systems whose decisions are opaque, creating trust gaps when lives are on the line. Dr. Sakib Mostafa’s work centers on explainable AI—the science of making AI decisions understandable…