Tag: genome stability
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Mutations in cGAS May Boost DNA Repair and Longevity in Naked Mole-Rats
Intro: A Hidden Genetic Edge for Longevity Why do naked mole-rats live so long, especially when compared with other rodents? A new study points to a subtle molecular difference that may help explain their remarkable genome stability. Researchers have identified specific evolutionary mutations in the DNA sensor cGAS (cyclic GMP-AMP synthase) that appear to bolster…
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Four Amino Acids Shape Naked Mole-Rat DNA Repair and Longevity
Unraveling a Longevity Secret: cGAS in Naked Mole-Rats For decades, naked mole-rats have puzzled scientists with their unusually long lifespans and robust genome maintenance. Reaching nearly 40 years in the wild, they outlive many rodents of similar size. A new line of inquiry suggests that subtle changes in a single enzyme of the innate immune…