Tag: genome stability
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Four Mutations that Help Naked Mole Rats Fix DNA and Live Longer
Introduction: A Tiny Rodent with Remarkable Longevity The naked mole rat (Heterocephalus glaber) is a small, hairless rodent native to East Africa famed for living up to 37 years—almost ten times longer than mammals of similar size. Researchers have long suspected that its longevity stems from genetic and cellular strategies that protect DNA, the blueprint…
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Four Mutations in Naked Mole Rats Extend DNA Repair and Longevity
New twist in aging science: naked mole rats and DNA repair The naked mole rat (Heterocephalus glaber) is not just famous for living up to about 37 years—nearly ten times longer than mammals of similar size. A groundbreaking study published in Science reveals a surprising mechanism behind this longevity: four amino acid changes in a…
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Mutations in cGAS May Boost DNA Repair and Longevity in Naked Mole-Rats
Intro: A Hidden Genetic Edge for Longevity Why do naked mole-rats live so long, especially when compared with other rodents? A new study points to a subtle molecular difference that may help explain their remarkable genome stability. Researchers have identified specific evolutionary mutations in the DNA sensor cGAS (cyclic GMP-AMP synthase) that appear to bolster…
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Four Amino Acids Shape Naked Mole-Rat DNA Repair and Longevity
Unraveling a Longevity Secret: cGAS in Naked Mole-Rats For decades, naked mole-rats have puzzled scientists with their unusually long lifespans and robust genome maintenance. Reaching nearly 40 years in the wild, they outlive many rodents of similar size. A new line of inquiry suggests that subtle changes in a single enzyme of the innate immune…