Tag: Genetics
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Genetic and Inflammatory Predictors of NDLVC Progression
Understanding nondilated left ventricular cardiomyopathy (NDLVC) NDLVC is a heart condition characterized by structural changes in the left ventricle without dilation. It can lead to symptoms ranging from none to heart failure, arrhythmias, or reduced exercise capacity. A recent large multicenter analysis published in the Canadian Journal of Cardiology highlights an important finding: nearly 40%…
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Improving Diagnosis of Aortic Stenosis with Genetics and AI
New Frontiers in Aortic Stenosis Diagnosis Aortic stenosis (AS) is a progressive narrowing of the aortic valve that constrains blood flow from the heart to the body. It affects millions worldwide and remains a leading cause of cardiovascular morbidity and mortality when not identified and managed early. Traditional diagnostic approaches rely on echocardiography, clinical assessment,…
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How Genetics and AI Are Transforming Aortic Stenosis Diagnosis
Overview: Aortic Stenosis Under the Lens Aortic stenosis, a narrowing of the aortic valve, restricts blood flow from the heart to the rest of the body. It is a common condition that can lead to heart failure if not detected and managed promptly. Traditionally, diagnosis relies on clinical evaluation, echocardiography, and imaging studies, but these…
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The Divided Mind by Edward Bullmore: Do We Now Know What Causes Schizophrenia?
Introduction: A timely re-examination Edward Bullmore’s The Divided Mind takes readers on a rigorous tour of what we know—and what remains stubbornly uncertain—about the origins of schizophrenia. Building on decades of neurobiology and clinical insight, the book surveys brain networks, genetics, and early-life experiences to ask a simple yet profound question: do we truly understand…
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Trichomoniasis in Cattle: Genetics, Heifer Care, and Bull Management Under the Microscope
Understanding Trichomoniasis in cattle and its real-world impact Trichomoniasis, caused by the protozoan parasite Tritrichomonas foetus, continues to challenge cattle herds around the world. Recent developments point to a nuanced picture: some calf abortions linked to the disease may involve inherited infection patterns, while other cases stem from management gaps in heifers and bulls. This…
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Trichomoniasis in Cattle: Genetics, Heifers and Bull Management
Understanding Trichomoniasis in cattle Trichomoniasis, caused by the protozoan parasite Tritrichomonas foetus, remains a notable reproductive disease affecting cattle herds globally. While clinical signs are often subtle, the impact on calving intervals and calf survival can be substantial. Recent research hints point to a complex mix of genetics, heifer exposure, and bull management as key…
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Upstream SOX9 Deletion and 46,XY Female with Acampomelic Campomelic Dysplasia: Absent Minipuberty
Overview Acampomelic campomelic dysplasia (ACD) is a subtler form of campomelic dysplasia characterized by skeletal anomalies without the classical bowed long bones. It results from haploinsufficiency or regulatory disruptions of the SOX9 gene, a pivotal regulator of chondrogenesis and sex development. In some cases, upstream deletions affecting the regulatory landscape of SOX9 lead to atypical…
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Three Diabetes Myths Debunked by a Gastro Doctor: Genetics Isn’t Destiny
Introduction: Myth-busting from a Gastro Doctor Many people assume that diabetes is a fixed fate dictated by genetics, with little room for change. Gastro doctor Dr. Pal challenges that notion, offering practical, science-backed advice on how daily habits influence blood sugar control. The message is hopeful: while genetics can raise risk, lifestyle choices often determine…
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From Ancient Wolves to Modern Breeds: The Emergence of Dog Varieties Over 10,000 Years
Unraveling the Timeline of Dog Breed Emergence Dogs are arguably the most diverse domesticated animals on the planet, with hundreds of breeds spanning a wide array of sizes, coats, temperaments, and skills. While the classic “Victorian era” tale highlights 19th-century breed standardization, emerging research paints a longer, richer picture: dog breeds began diverging more than…
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Ancient Origins of Dog Breeds: Emergence Over 10,000 Years
Introduction: The long road of dog breeds Dogs today come in a stunning array of shapes, sizes, and temperaments. From tiny lap dogs to sturdy working breeds, the diversity of dog breeds has long fascinated scientists, historians, and pet lovers alike. While the most dramatic changes in appearance are often linked to the 19th‑century Victorian…